Caprani, Adrien

Gerbaud, Laurent

Tran, Guy Mong Ky

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Guy Tran

Laurent Gerbaud

Adrien Caprani

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Auto-immune thrombocytopenia after Measles Mumps Rubella MMR vaccination: molecular mimicry of measles virus phosphoprotein with platelet gpIIb

Gerbaud Laurent

Tran Guy

Caprani Adrien

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Retrovirology

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POSTER PRESENTATION Open Access
Auto-immune thrombocytopenia after Measles
Mumps Rubella MMR vaccination: molecular
mimicry of measles virus phosphoprotein
with platelet gpIIb
Guy Mong Ky Tran1,2, Laurent Gerbaud1, Adrien Caprani2*
From 16th International Symposium on HIV and Emerging Infectious Diseases
Marseille, France. 24-26 March 2010
Background
MMR vaccination is complicated by rare cases of auto-
immune purpura or thrombocytopenia in a chronologi-
cal delay of about 10-24 days, which corresponds to the
rise of antibodies (Autret E, 1996; Vlacha V, 1996). We
have demonstrated that in the cases of HIV-1, Parvo-
virus B19, Chikungunya virus, Leptospirosis, the culprit
is an epitope localized on the platelet gpIIIaIIb, centred
by a phenylalanine-proline (Tran MKG, ISHEID Toulon
2002); these auto-antibodies are very powerful and
induce in mice a thrombocytopenia; allo-immunisation
from mother to the newborn has the same epitope on
gpIIIaIIb (Brouk H, 2009). We continue the same direc-
tion of research for MMR vaccine.
Methods
Comparison of amino acid sequences between gpIIIaIIb
and viruses (measles, mumps and rubella).
Results
There is a molecular mimicry between gpIIb (P08514)
and measles virus (strain MVi/Victoria.Aus/12.99) Phos-
phoprotein P (ABV24494) (Bankamp B, 2008), Table 1.
Discussion
The occurrence of thrombocytopenia 2 or 3 weeks after
MMR vaccination is an auto-immune phenomenon, on a
peculiar genetic background prone to make auto-antibo-
dies against phenylalanine-proline containing epitopes.
MMR vaccine must be avoided in these patients with
idiopathic thrombocytopenia (Drachtman RA, 1994). The
chronological argument is by itself convincing and con-
firmed here by the biological finding of the causal epitope
on platelet. Thus we must be very cautious in presence of
a MMR vaccine clinical auto-immune complication (such
as autism) (Wakefield AJ) and not discard it as a simple
coincidence, but rather try to elucidate its mechanism
and genetics (HLA-DR4). The gpIIIaIIb epitope may
serve as a chelating hapten for treatment.
Author details
1University of Auvergne, Hotel-Dieu Hospital, Clermont-Ferrand, France.
2Association Positifs, Paris, France.
Published: 11 May 2010
doi:10.1186/1742-4690-7-S1-P173
Cite this article as: Tran et al.: Auto-immune thrombocytopenia after
Measles Mumps Rubella MMR vaccination: molecular mimicry of
measles virus phosphoprotein with platelet gpIIb. Retrovirology 2010
7(Suppl 1):P173.
* Correspondence: positifpresident@yahoo.fr
2Association Positifs, Paris, France
Tabele 1
platelet gpIIb 782 RGNSFP
Measles virus P protein 199-RGNSFP-204
Tran et al. Retrovirology 2010, 7(Suppl 1):P173
http://www.retrovirology.com/content/7/S1/P173
© 2010 Tran et al; licensee BioMed Central Ltd.


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Auto-immune thrombocytopenia after Measles Mumps Rubella MMR vaccination: molecular mimicry of measles virus phosphoprotein with platelet gpIIb

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