Type 1 diabetes (T1D) is the most common chronic metabolic disease in children and
adolescents. The etiology of T1D is not fully understood but it seems multifactorial. The genetic
background determines the predisposition to develop T1D, while the autoimmune process against
-cells seems to be also determined by environmental triggers, such as endocrine disrupting chemicals
(EDCs). Environmental EDCs may act throughout dierent temporal windows as single chemical
agent or as chemical mixtures. They could aect the development and the function of the immune
system or of the beta-cells function, promoting autoimmunity and increasing the susceptibility to
autoimmune attack. Human studies evaluating the potential role of exposure to EDCs on the
pathogenesis of T1D are few and demonstrated contradictory results. The aim of this narrative review
is to summarize experimental and epidemiological studies on the potential role of exposure to EDCs in
the development of T1D.We highlight what we know by animals about EDCs\u2019 eects on mechanisms
leading to T1D development and progression. Studies evaluating the EDC levels in patients with T1D
were also reported. Moreover, we discussed why further studies are needed and how they should be
designed to better understand the causal mechanisms and the next prevention interventions
