Background and aim of the work. Due to the ageing of cancer patients, new approaches that require
a more active participation in the self-management of cancer treatment at home are needed. Nurses are strategic
in improving the patient\u2019s engagement capability in this regard. Knowing which interventions are more
effective for the promotion of patient engagement could be useful to improve the effectiveness of the care
provided. Therefore, this study aims to systematically review nursing interventions or programs that promote
patient engagement in oncological nursing care and summarizing the main evidence related to their impact
on relevant clinical and psychosocial outcomes. Method. This is a systematic review and meta-analysis protocol
based on Cochrane Handbook for the systematic review of interventions. We will search the most important
electronic databases (PUBMED, CINAHL, EMBASE, SCOPUS, ISI Web of Science, Cochrane library) to
find out which patient engagement interventions (active adult patient involvement) are implemented in oncological
settings and understand what is the effectiveness of these interventions on the outcomes reported in the
literature. The GRADE methodology will be used to synthetize the evidence. If possible, also a meta-analysis
will be performed. We registered the study protocol on the PROSPERO database (N\ub0 CRD42020146189).
Discussion and Conclusion. To our knowledge, this is the first systematic review to address this clinical question
in the field of oncology. This review will offer health professionals indications on the most frequently adopted
patient engagement interventions and verify their clinical effectiveness. Furthermore, any gaps in the scientific
literature will be highlighted