Despite the ambitious goals of promoting inclusive growth in the Europe 2020 strategy, the number of people at risk of poverty in European Union is still growing. The paper moves from the hypothesis that poverty may show distinctive social patterns, which couple with a given spatial dimension and therefore can be defined as a spatially heterogeneous phenomenon at both national and sub-national level. Using the available data from Eurostat on income and living conditions (EUSILC) at NUTS2 level, the paper highlights the different territorial patterns in shaping the risk of exclusion across the EU regions. Focusing on the regions of the Southern and Eastern peripheral EU Member States (MSs), the paper outlines the differences emerging from the results achieved by the EU MSs in applying the Europe 2020 Strategy. Moreover, it deepens the analysis of the poverty drivers at the regional level. The paper shows that the peripheral countries of EU are more vulnerable to poverty but different patterns emerge when comparing Mediterranean and Eastern countries, especially with regard to the material deprivation and the drivers influencing poverty and risk of exclusion