The present invention pertains to the field of T Cell receptors (TCR) identification and clonotyping, and especially concerns particular TCRs identified by clonotyping of a HIV-specific TCR repertoire, or fragments thereof. the invention relates especially to TCRs recognizing Gag peptide located between positions 293-312 in the GAG protein of HIV-1.
The present invention further relates to nucleic acid constructs suitable as means for cloning or expressing nucleic acid molecules or TCRs of the invention, such as plasmids, vectors, especially lentiviral transfer vectors. The invention is of particular interest in the context of therapeutic treatment of human beings seropositive for HIV
