Current diagnostic systems, DSM-5 and ICD-10, still adopt a categorical approach to classify psychotic disorders. The present study was aimed at investigating the structure of psychotic symptomatology in both affective and non-affective psychosis from a dimensional approach

Bettini, Elena

Bonetto, Chiara

Cellini, Massimo

Comacchio, Carla

Cristofalo, Doriana

D'Agostino, Armando

DE GIROLAMO, Giovanni

De Santi, Katia

Fioritti, Angelo

Ghigi, Daniela

Iozzino, Laura

Lasalvia, Antonio

Lenzi, Jacopo

Leuci, Emanuela

Marchesi, Carlo

Meneghelli, Anna

Miceli, Maurizio

Ossola, Paolo

Pileggi, Francesca

Rucci, Paola

Ruggeri, Mirella

Santonastaso, Paolo

Scarone, Silvio

Tonna, Matteo

Torresani, Stefano

Tosato, Sarah

Veronese, Angela

de Girolamo, Giovanni

Catalogo dei prodotti della ricerca

Dimensional structure of first episode psychosis

Aim: Current diagnostic systems, DSM-5 and ICD-10, still adopt a categorical approach to classify psychotic disorders. The present study was aimed at investigating the structure of psychotic symptomatology in both affective and non-affective psychosis from a dimensional approach.

Methods: Participants with a first episode psychosis (FEP) were recruited from a cluster-randomized controlled trial (GET-UP PIANO TRIAL), offered to all Community Mental Health Centres (CMHCs) located across two northern Italian regions. After clinical stabilization, patients were assessed with a comprehensive set of psychopathological measures including the Positive and Negative Syndrome Scale, the Hamilton Depression Rating Scale and the Bech-Rafaelsen Mania Rating Scale. A two-step cluster analysis was performed.

Results: Overall, 257 FEP patients (male, n = 171, 66.5%; mean age = 24.96 ± 4.56) were included in the study. The cluster analysis revealed a robust four-cluster solution: delusional-persecutory (n = 82; 31.9%), depressed (n = 95; 37%), excited (n = 26; 10.1%) and negative-disorganized (n = 54; 21%), thus suggesting a quadripartite structure with both affective and non-affective dimensions. Among non-affective dimensions, negative and disorganization symptoms constituted a unique construct apart from positive symptoms.

Conclusions: Symptom dimensions may represent a useful tool for dissecting the indistinct and non-specific psychopathology of FEP in order to better target specific interventions

Tonna M

Ossola P

Marchesi C

Bettini E

Lasalvia A

Bonetto C

Lenzi J

Rucci P

Iozzino L

Cellini M

Comacchio C

Cristofalo D

D'Agostino A

de Girolamo G

De Santi K

Ghigi D

Leuci E

Miceli M

Meneghelli A

Pileggi F

Scarone S

Santonastaso P

Torresani S

Tosato S

Veronese A

Fioritti A

Ruggeri M

Archivio istituzionale della Ricerca -  Università degli Studi di Parma

Aim: Current diagnostic systems, DSM-5 and ICD-10, still adopt a categorical approach to classify psychotic disorders. The present study was aimed at investigating the structure of psychotic symptomatology in both affective and non-affective psychosis from a dimensional approach. Methods: Participants with a first episode psychosis (FEP) were recruited from a cluster-randomized controlled trial (GET-UP PIANO TRIAL), offered to all Community Mental Health Centres (CMHCs) located across two northern Italian regions. After clinical stabilization, patients were assessed with a comprehensive set of psychopathological measures including the Positive and Negative Syndrome Scale, the Hamilton Depression Rating Scale and the Bech-Rafaelsen Mania Rating Scale. A two-step cluster analysis was performed. Results: Overall, 257 FEP patients (male, n = 171, 66.5%; mean age = 24.96 \ub1 4.56) were included in the study. The cluster analysis revealed a robust four-cluster solution: delusional-persecutory (n = 82; 31.9%), depressed (n = 95; 37%), excited (n = 26; 10.1%) and negative-disorganized (n = 54; 21%), thus suggesting a quadripartite structure with both affective and non-affective dimensions. Among non-affective dimensions, negative and disorganization symptoms constituted a unique construct apart from positive symptoms. Conclusions: Symptom dimensions may represent a useful tool for dissecting the indistinct and non-specific psychopathology of FEP in order to better target specific interventions

M. Tonna

P. Ossola

C. Marchesi

E. Bettini

A. Lasalvia

C. Bonetto

J. Lenzi

P. Rucci

L. Iozzino

M. Cellini

C. Comacchio

D. Cristofalo

A. D&apos

G. de Girolamo

K. De Santi

D. Ghigi

E. Leuci

M. Miceli

A. Meneghelli

F. Pileggi

S. Scarone

P. Santonastaso

S. Torresani

S. Tosato

A. Veronese

A. Fioritti

M. Ruggeri

AIR Universita degli studi di Milano

Bleuler E.

Costello A. B.

Petruzzelli M. G.

World Health Organization

Crossref

DE GIROLAMO, GIOVANNI

TOSATO, SARAH

Archivio istituzionale della ricerca - Università di Modena e Reggio Emilia

AIM: Current diagnostic systems, DSM-5 and ICD-10, still adopt a categorical approach to classify psychotic disorders. The present study was aimed at investigating the structure of psychotic symptomatology in both affective and non-affective psychosis from a dimensional approach. METHODS: Participants with a first episode psychosis (FEP) were recruited from a cluster-randomized controlled trial (GET-UP PIANO TRIAL), offered to all Community Mental Health Centres (CMHCs) located across two northern Italian regions. After clinical stabilization, patients were assessed with a comprehensive set of psychopathological measures including the Positive and Negative Syndrome Scale, the Hamilton Depression Rating Scale and the Bech-Rafaelsen Mania Rating Scale. A two-step cluster analysis was performed. RESULTS: Overall, 257 FEP patients (male, n = 171, 66.5%; mean age = 24.96 ± 4.56) were included in the study. The cluster analysis revealed a robust four-cluster solution: delusional-persecutory (n = 82; 31.9%), depressed (n = 95; 37%), excited (n = 26; 10.1%) and negative-disorganized (n = 54; 21%), thus suggesting a quadripartite structure with both affective and non-affective dimensions. Among non-affective dimensions, negative and disorganization symptoms constituted a unique construct apart from positive symptoms. CONCLUSIONS: Symptom dimensions may represent a useful tool for dissecting the indistinct and non-specific psychopathology of FEP in order to better target specific interventions

Tonna M.

Ossola P.

Marchesi C.

Bettini E.

Lasalvia A.

Bonetto C.

Lenzi J.

Rucci P.

Iozzino L.

Cellini M.

Comacchio C.

Cristofalo D.

D'Agostino A.

de Girolamo G.

De Santi K.

Ghigi D.

Leuci E.

Miceli M.

Meneghelli A.

Pileggi F.

Scarone S.

Santonastaso P.

Torresani S.

Tosato S.

Veronese A.

Fioritti A.

Ruggeri M.

Archivio istituzionale della ricerca - Alma Mater Studiorum Università di Bologna

Dimensional structure of first episode psychosis

Abstract

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Catalogo dei prodotti della ricerca

Archivio istituzionale della Ricerca - Università degli Studi di Parma

AIR Universita degli studi di Milano

Crossref

Archivio istituzionale della ricerca - Università di Modena e Reggio Emilia

Archivio istituzionale della ricerca - Alma Mater Studiorum Università di Bologna