The paper collects together and describes the main and most known Agile methodologies. Those methodologies are then compared in order to assess their fit in the context of highly innovative non-software companies. In particular, the focus is on a full system supplier for food processing and packaging equipment, packaging material and services. The fit between the Agile methodologies and the company is performed considering the innovation and development processes in place into the Research and Development department of the company itself. By doing so the paper aims at contributing to the theme of Agile application in non-software industries. Moreover, it will support in the choice of which method or framework suits better having clear the needs and
characteristics of that specific context. Finally, the paper provides also a suggestion about how to approach this kind of choices
