On-demand drug delivery from polymeric implants by external triggering

Abstract

In this contribution, a novel on demand drug delivery concept based on polymeric implants is presented. The simple combination of drug substance and polymer matrix was found to result in a robust and reproducible on demand drug delivery device that can be switched by temp. High switching ratios (several hundreds) were found in repetitive (up to 5) on demand drug dosing. In addn., the use of several other noninvasive triggers was explored. Finally, the potential of this novel drug delivery technol. will be demonstrated by in vivo on demand drug delivery