First 1,3-Dipolar Cycloaddition of Azomethine Ylides With (E)-Ethyl 3-Fluoroacrylate. Regio- and Stereoselective Synthesis of Enantiopure Fluorinated Prolines.
Enantiopure fluorinated prolines with four chiral centers were obtained from 1,3-dipolar cycloaddition of azomethine ylides and (E)-ethyl 3-fluoroacrylate