A significant number of students try alcohol, tobacco or other drugs as teenagers. More than 65 percent of students have used alcohol, more than 40 percent used illegal drugs and around one-quarter used cigarettes at some point before entering or while in high school. While the number of teens who regularly misuse or develop substance use disorders has been decreasing over time, overall levels are still too high. In this report, the Trust for America's Health (TFAH) examines how to help move towards a strong prevention-oriented, continuum-of-care approach to substance misuse -- looking at policies and programs that have a high impact for improving the well-being of America's youth