A multimodality protocol combining endoscopic MRI and confocal endomicroscopy for mice colorectal lesions assessment

Abstract

International audiencePatients with inflammatory bowel disease (IBD) are at higher risk to develop colorectal cancer (CCR) [1]. An early diagnosis and characterization of abnormalities can help to adapt therapeutic responses and increase treatments efficiency. Endoscopy and confocal endomicroscopy (CEM) are used to characterize macroscopic features and vascular network architecture of the parietal surface. By contrast, MRI, performed with endoluminal coils (EC) [2], allows to image deeper colon-wall layers and visceral fat. The aim of this work was to follow colon tissues infiltration on a mouse model of colitis during a six months period time using endoluminal optics and MRI

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