Degradation of YRA1 Pre-mRNA in the Cytoplasm Requires Translational Repression, Multiple Modular Intronic Elements, Edc3p, and Mex67p

A van Hoof; A-C Gavin; A. E Pasquinelli; Allan Jacobson; C Barreau; C Guthrie; C Keierleber; C. A Beelman; C. J Decker; C. Y Chen; C. Y Chen; D Mukherjee; D. A Mangus; F He; F He; F He; F Tritschler; Feng He; G Badis; H Santos-Rosa; I Stansfield; J Coller; J Lykke-Andersen; J Vilardell; J. R Anderson; K. M Forrest; L Jin; M Fromont-Racine; M Kshirsagar; M. K Doma; Marv Wickens; N Amrani; N Paquin; N. G Kolev; P Gruter; P Legrain; P Uetz; P. A Frischmeyer; S Crucs; S Dong; S Vasudevan; S Zhang; Shuyun Dong; T Gross; T Ito; T. A Bolger; V Galy; W. J Lin; Y Ho; Y Li

Degradation of YRA1 Pre-mRNA in the Cytoplasm Requires Translational Repression, Multiple Modular Intronic Elements, Edc3p, and Mex67p

Authors: A van Hoof
A-C Gavin
A. E Pasquinelli
Allan Jacobson
C Barreau
C Guthrie
C Keierleber
C. A Beelman
C. J Decker
C. Y Chen
C. Y Chen
D Mukherjee
D. A Mangus
F He
F He
F He
F Tritschler
Feng He
G Badis
H Santos-Rosa
I Stansfield
J Coller
J Lykke-Andersen
J Vilardell
J. R Anderson
K. M Forrest
L Jin
M Fromont-Racine
M Kshirsagar
M. K Doma
Marv Wickens
N Amrani
N Paquin
N. G Kolev
P Gruter
P Legrain
P Uetz
P. A Frischmeyer
S Crucs
S Dong
S Vasudevan
S Zhang
Shuyun Dong
T Gross
T Ito
T. A Bolger
V Galy
W. J Lin
Y Ho
Y Li
Publication date: 1 April 2010
Publisher: Public Library of Science
Doi

Abstract

The yeast YRA1 pre-mRNA contains multiple intronic elements that regulate transcript decay and translatability via the Edc3p decapping activator and the Mex67p/Mtr2p export receptor

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