Background: The opioid system is involved in reward and pain mechanisms and consists in mammals of four receptors an

Dan Larhammar

Görel Sundström

Robert DeSalle

Susanne Dreborg

PLoS ONE

English

PubMed

BACKGROUND: The opioid system is involved in reward and pain mechanisms and consists in mammals of four receptors and several peptides. The peptides are derived from four prepropeptide genes, PENK, PDYN, PNOC and POMC, encoding enkephalins, dynorphins, orphanin/nociceptin and beta-endorphin, respectively. Previously we have described how two rounds of genome doubling (2R) before the origin of jawed vertebrates formed the receptor family. METHODOLOGY/PRINCIPAL FINDINGS: Opioid peptide gene family members were investigated using a combination of sequence-based phylogeny and chromosomal locations of the peptide genes in various vertebrates. Several adjacent gene families were investigated similarly. The results show that the ancestral peptide gene gave rise to two additional copies in the genome doublings. The fourth member was generated by a local gene duplication, as the genes encoding POMC and PNOC are located on the same chromosome in the chicken genome and all three teleost genomes that we have studied. A translocation has disrupted this synteny in mammals. The PDYN gene seems to have been lost in chicken, but not in zebra finch. Duplicates of some peptide genes have arisen in the teleost fishes. Within the prepropeptide precursors, peptides have been lost or gained in different lineages. CONCLUSIONS/SIGNIFICANCE: The ancestral peptide and receptor genes were located on the same chromosome and were thus duplicated concomitantly. However, subsequently genetic linkage has been lost. In conclusion, the system of opioid peptides and receptors was largely formed by the genome doublings that took place early in vertebrate evolution

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Concomitant duplications of opioid peptide and receptor genes before the origin of jawed vertebrates.

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Concomitant Duplications of Opioid Peptide and Receptor Genes before the Origin of Jawed Vertebrates

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Analysis of lamprey and hagfish genes reveals a complex history of gene duplications during early vertebrate evolution.

Analyzing the evolution of the opioid/orphanin gene family.

Basic local alignment search tool.

Characterization of zebrafish proenkephalin reveals novel opioid sequences.

Cloning and characterization of a full-length pronociceptin in zebrafish: evidence of the existence of two different nociceptin sequences in the same precursor.

Cloning and characterization of Xen-dorphin prohormone from Xenopus laevis: a new opioid-like prohormone distinct from proenkephalin and prodynorphin.

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.

Comparative structural analysis of the transcriptionally active proopiomelanocortin genes A and B of Xenopus laevis.

Early vertebrate chromosome duplications and the evolution of the neuropeptide Y receptor gene regions.

Endogenous opiates and behavior:

Evolution of the Fgf and Fgfr gene families. Trends Genet 20: 563–569.

Evolution of the neuropeptide Y family: New genes by chromosome duplications in early vertebrates and in teleost fishes.

Evolution of vertebrate opioid receptors.

From 2R to 3R: evidence for a fish-specific genome duplication (FSGD).

Hormones and receptors in fish: do duplicates matter?

Identification and localization of a [Met5]-enkephalin-like peptide in the mollusc, Lymnaea stagnalis.

Identification of a fourth opioid core sequence in a prodynorphin cDNA cloned from the brain of the amphibian, Bufo marinus: deciphering the evolution of prodynorphin and proenkephalin.

Identification of the ron gene product as the receptor for the human macrophage stimulating protein.

Isolation, sequence analysis, and physiological properties of enkephalins in the nervous tissue of the shore crab Carcinus maenas L.

Multiple sequence alignment with Clustal X.

Nocistatin: a novel neuropeptide encoded by the gene for the nociceptin/orphanin FQ precursor.

Occurrence of two functionally distinct proopiomelanocortin genes in all modern lampreys.

Opiate-like substances in an invertebrate, an opiate receptor on invertebrate and human immunocytes, and a role in immunosuppression.

Opioid receptors: from binding sites to visible molecules in vivo.

Phylogeny, taxonomy, and evolution of the endothelin receptor gene family.

Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery.

Salaneck E (2004) Phylogeny of NPY-family peptides and their receptors.

Structural and functional diversity of proopiomelanocortin in fish with special reference to barfin flounder.

Sturgeon orphanin, a molecular ‘‘fossil’’ that bridges the gap between the opioids and orphanin FQ/nociceptin.

Subfunctionalization of expression and peptide domains following the ancient duplication of the proopiomelanocortin gene in teleost fishes.

The amphioxus genome and the evolution of the chordate karyotype.

The endothelin system: evolution of vertebrate-specific ligand-receptor interactions by three rounds of genome duplication.

The evolution of neuroendocrine peptides.

The orphanin FQ/nociceptin (OFQ/N) system.

Timing and mechanism of ancient vertebrate genome duplications — the adventure of a hypothesis.

Timing of genome duplications relative to the origin of the vertebrates: did cyclostomes diverge before or after?

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Unusual linkage patterns of ligands and their cognate receptors indicate a novel reason for non-random gene order in the human genome.

von Haeseler A

http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.355.5370

Concomitant Duplications of Opioid Peptide and Receptor Genes before the Origin of Jawed Vertebrates

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