Artículo de publicación ISIInvasive pneumococcal disease (IPD) remains as an important cause of morbidity in the world and in our
country, while in Chile the incidence has decreased after the incorporation of the 10 valent pneumococcal conjugate
vaccine, in the routine infant inmunization schedule (EPI). One of the expected effects of the program after
vaccination with 10-valent pneumococcal vaccine is the likely replacement serotype phenomenon that means the
presence of ENI caused by serotypes not included in the vaccine. In this context, we present the case of a child
with pneumococcal meningitis caused by serotype 19 A of fatal course. The occurrence of ENI in a later stage of
pneumococcal vaccine incorporation in Chile reinforces the importance of active surveillance, in order to know
in detail the impact of vaccination, distribution of circulating serotypes and their correlation with the different
clinical disease and their severity
