MGOUN1 Encodes an Arabidopsis Type IB DNA Topoisomerase Required in Stem Cell Regulation and to Maintain Developmentally Regulated Gene Silencing[W]

Abstract

This work examines the function of MGOUN1 (MGO1) in Arabidopsis stem cell maintenance, showing that mgo1 mutations enhance the specific stem cell defects in hypomorphic wuschel alleles. Positional cloning reveals that MGO1 encodes topoisomerase IB, thereby linking topoisomerase function to the propagation of developmentally regulated gene function