Anderson TW

Baush-Goldbohm RA

Durlach J

Elin RJ

Galan P

Goldbohm RA

Landin K

Leo J. Schouten

Lina J. Leurs

Margreet N. Mons

Mons M

Nederlandse Voedings Middelen Tabel

Piet A. van den Brandt

R. Alexandra Goldbohm

Sinclair MI

Theophanides T

VEWIN (Vereniging van Exploitanten van Waterbedrijven in Nederland)

Environmental Health Perspectives

English

PubMed

BACKGROUND: Conflicting results on the relationship between the hardness of drinking water and mortality related to ischemic heart disease (IHD) or stroke have been reported. OBJECTIVES: We investigated the possible association between tap water calcium or magnesium concentration and total hardness and IHD mortality or stroke mortality. METHODS: In 1986, a cohort of 120,852 men and women aged 55-69 years provided detailed information on dietary and other lifestyle habits. Follow-up for mortality until 1996 was established by linking data from the Central Bureau of Genealogy and Statistics Netherlands. We calculated tap water hardness for each postal code using information obtained from all pumping stations in the Netherlands. Tap water hardness was categorized as soft [ 2.0 mmol/L CaCO(3)). The multivariate case-cohort analysis was based on 1,944 IHD mortality and 779 stroke mortality cases and 4,114 subcohort members. RESULTS: For both men and women, we observed no relationship between tap water hardness and IHD mortality [hard vs. soft water: hazard ratio (HR) = 1.03; 95% confidence interval (CI), 0.85-1.28 for men and HR = 0.93; 95% CI, 0.71-1.21 for women) and stroke mortality (hard vs. soft water HR = 0.90; 95% CI, 0.66-1.21 and HR = 0.86; 95% CI, 0.62-1.20, respectively). For men with the 20% lowest dietary magnesium intake, an inverse association was observed between tap water magnesium intake and stroke mortality (HR per 1 mg/L intake = 0.75; 95% CI, 0.61-0.91), whereas for women with the 20% lowest dietary magnesium intake, the opposite was observed. CONCLUSIONS: We found no evidence for an overall significant association between tap water-hardness, magnesium or calcium concentrations, and IHD mortality or stroke mortality. More research is needed to investigate the effect of tap water magnesium on IHD mortality or stroke mortality in subjects with low dietary magnesium intake

Leurs, Lina J.

Schouten, Leo J.

Mons, Margreet N.

Goldbohm, R. Alexandra (Sandra)

van den Brandt, Piet A.

NARCIS 

Relationship between Tap Water Hardness, Magnesium, and Calcium Concentration and Mortality due to Ischemic Heart Disease or Stroke in the Netherlands

BACKGROUND: Conflicting results on the relationship between the hardness of drinking water and mortality related to ischemic heart disease (IHD) or stroke have been reported. OBJECTIVES: We investigated the possible association between tap water calcium or magnesium concentration and total hardness and IHD mortality or stroke mortality. METHODS: In 1986, a cohort of 120,852 men and women aged 55-69 years provided detailed information on dietary and other lifestyle habits. Follow-up for mortality until 1996 was established by linking data from the Central Bureau of Genealogy and Statistics Netherlands. We calculated tap water hardness for each postal code using information obtained from all pumping stations in the Netherlands. Tap water hardness was categorized as soft [&lt;1.5 mmol/L calcium carbonate (CaCO(3))], medium hard (1.6-2.0 mmol/L CaCO(3)), and hard (&gt; 2.0 mmol/L CaCO(3)). The multivariate case-cohort analysis was based on 1,944 IHD mortality and 779 stroke mortality cases and 4,114 subcohort members. RESULTS: For both men and women, we observed no relationship between tap water hardness and IHD mortality [hard vs. soft water: hazard ratio (HR) = 1.03; 95% confidence interval (CI), 0.85-1.28 for men and HR = 0.93; 95% CI, 0.71-1.21 for women) and stroke mortality (hard vs. soft water HR = 0.90; 95% CI, 0.66-1.21 and HR = 0.86; 95% CI, 0.62-1.20, respectively). For men with the 20% lowest dietary magnesium intake, an inverse association was observed between tap water magnesium intake and stroke mortality (HR per 1 mg/L intake = 0.75; 95% CI, 0.61-0.91), whereas for women with the 20% lowest dietary magnesium intake, the opposite was observed. CONCLUSIONS: We found no evidence for an overall significant association between tap water-hardness, magnesium or calcium concentrations, and IHD mortality or stroke mortality. More research is needed to investigate the effect of tap water magnesium on IHD mortality or stroke mortality in subjects with low dietary magnesium intake

Maastricht University Research Portal

Crossref

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2854772

Relationship between Tap Water Hardness, Magnesium, and Calcium Concentration and Mortality due to Ischemic Heart Disease or Stroke in the Netherlands

Abstract

Similar works

Full text

Available Versions

NARCIS

Maastricht University Research Portal

Maastricht University Research Portal

Crossref