The use of ultrasound guidance in prostate cancer radiotherapy workflows is not widespread. This can be partially attributed to the need for image interpretation by a trained operator during ultrasound image acquisition. In this work, a one-class regressor, based on DenseNet and Gaussian processes, was implemented to assess automatically the quality of transperineal ultrasound images of the male pelvic region. The implemented deep learning approach achieved a scoring accuracy of 94%, a specificity of 95% and a sensitivity of 93% with respect to the majority vote of three experts, which was comparable with the results of these experts. This is the first step towards a fully automatic workflow, which could potentially remove the need for image interpretation and thereby make the use of ultrasound imaging, which allows real-time volumetric organ tracking in the RT environment, more appealing for hospitals