Au, M

Chuang, Chia Lin

Cooper, Garth

Li, Xiaoling

Liu, Hong

Phillips, Anthony R. J.

Scott, David W.

Zhang, Lin

Zhang, S

The FASEB Journal

English

Shaoping Zhang

Hong Liu

Chia Lin Chuang

Xiaoling Li

Maggie Au

Lin Zhang

Anthony R. J. Phillips

David W. Scott

Garth J. S. Cooper

Crossref

The pathogenic mechanism of diabetes varies with the degree of overexpression and oligomerization of human amylin in the pancreatic islet β cells

The aggregation of human amylin (hA) to form cytotoxic structures has been closely associated with the causation of type 2 diabetes. We sought to advance understanding of how altered expression and aggregation of hA might link Î²-cell degeneration with diabetes onset and progression, by comparing phenotypes between homozygous and hemizygous hA-transgenic mice. The homozygous mice displayed elevated islet hA that correlated positively with measures of oligomer formation (r=0.91; 

The University of Manchester - Institutional Repository

The pathogenic mechanism of diabetes varies with the degree of overexpression and oligomerization of human amylin in the pancreatic islet Î² cells

https://pure.manchester.ac.uk/ws/files/28590030/POST-PEER-REVIEW-PUBLISHERS.PDF

The pathogenic mechanism of diabetes varies with the degree of overexpression and oligomerization of human amylin in the pancreatic islet Î² cells

Abstract

Similar works

Full text

Available Versions

Crossref

The University of Manchester - Institutional Repository