Adachi, JD

Beattie, KA

Boulos, P

Duryea, J

Gordon, CL

Inglis, D

Ioannidis, G

Webber, CE

English

PubMed

Boulos, Pauline

Inglis, Dean

Beattie, Karen A.

Ioannidis, George

Gordon, C. L.

Duryea, Jeffrey

Webber, Colin E.

Adachi, Jonathan D.

Harvard University - DASH

 Magnetic resonance imaging, X-ray and dual X-ray absorptiometrytechniques for assessment and monitoring of knee osteoarthritis  (Article begins on next page)The Harvard community has made this article openly available.Please share how this access benefits you. Your story matters.Citation Boulos, Pauline, Dean Inglis, Karen A. Beattie, George Ioannidis,C. L. Gordon, Jeffrey Duryea, Colin E. Webber, and Jonathan D.Adachi.  2004.  Magnetic resonance imaging, X-ray and dual X-ray absorptiometry techniques for assessment and monitoring ofknee osteoarthritis. Arthritis Research & Therapy 6 (Suppl 3): 102.Published Version doi:10.1186/ar1437Accessed February 19, 2015 3:42:53 AM ESTCitable Link http://nrs.harvard.edu/urn-3:HUL.InstRepos:4789782Terms of Use This article was downloaded from Harvard University's DASHrepository, and is made available under the terms and conditionsapplicable to Other Posted Material, as set forth athttp://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAAS41References1. Insall J: Current concepts review: patellar pain. J Bone JointSurg Am 1982, 64:147-152.2. Fellows RA, Hill NA, Gill HS, MacIntyre NJ, Harrison MM, Ellis RE,Wilson DR: Magnetic resonance imaging for in vivo assess-ment of three-dimensional patellar tracking. J Biomech, inpress.3. Katchburian MV, Bull AM, Shih YF, Heatley FW, Amis AA: Mea-surement of patellar tracking: assessment and analysis of theliterature. Clin Orthop 2003, 412:241-259.Acknowledgements Supported by grants from Canadian Institutes ofHealth Research (CIHR), NSERC, and Physiotherapy Foundation ofCanada. Salary support was awarded by The Arthritis Society/CIHR(Research Fellowship, NJM) and the Canadian Arthritis Network(DRW).101 (P11.2)Perceived need for workplace accommodation andlabour force participation in Canadian adults witharthritis disabilityPP Wang, EM Badley, M GignacArthritis Community Research and Evaluation Unit, Department ofPublic Health Sciences, University of Toronto, Toronto, Ontario,CanadaArthritis Res Ther 2004, 6(Suppl 3):101 (DOI 10.1186/ar1436)Purpose Although reduced labour force participation is often a conse-quence of physical disability, little is known about the role of workplaceaccommodation. This study uses a conceptual model based on theWorld Health Organization International Classification of Functioning,Disability, and Health and hypothesizes perceived need for workplaceaccommodation as a mediating variable between activity limitation andnot in labour force.Methods Data from the Canadian Health and Activity Limitation Surveywere used. Working-age participants (25–64 years) with arthritis dis-ability were included. Employment status was dichotomized into 0 = inlabour force (employed and unemployed), 1 = not in labour force. Twolatent constructs (lower body and upper body disability) were used torepresent 12 categorical physical disability indicators (e.g. difficulty inwalking) and one latent construct was derived for eight workplaceaccommodation indicators (e.g. lack of accessible workstation, elevatoror flexible hours if needed). Personal variables (age, sex, education, andoccupation) were also incorporated into the model. MPLUS was usedto perform the categorical factor analysis and standard error of themean analyses.Results Physical activity limitations affected labour force participationboth directly and indirectly through perceived need for workplaceaccommodation. As people’s activity limitations became severe theywere more likely to perceive the need for workplace accommodation,and in turn, this lead to reduced labour force participation. Lower bodyactivity limitations had more impact on labour force than upper bodyactivity limitation. Older age, female gender, and low education werealso associated with reduced labour force participation.Conclusion Most of the effect of arthritis-associated physical activitylimitations and all on labour force participation is mediated by per-ceived workplace accommodation, which underscores the importanceof workplace accommodation provision.102 (P11.3)Magnetic resonance imaging, X-ray and dual X-rayabsorptiometry techniques for assessment andmonitoring of knee osteoarthritisP Boulos1,2, D Inglis2, KA Beattie2, G Ioannidis2, CL Gordon2, J Duryea3, CE Webber2,4, JD Adachi1,21Department of Medicine, St Joseph’s Healthcare, Hamilton, Ontario,Canada; 2McMaster University, Hamilton, Ontario, Canada;3Department of Radiology, Brigham and Women’s Hospital, HarvardUniversity, Boston, Massachusetts, USA; 4Department of NuclearMedicine, Hamilton Health Sciences, Hamilton, Ontario, CanadaArthritis Res Ther 2004, 6(Suppl 3):102 (DOI 10.1186/ar1437)Aims Research projects completed and ongoing by members of ourresearch team include: (i) validation of quantitative cartilage measure-ments using a 1 T extremity magnetic resonance imaging (MRI)scanner; (ii) radiographic evaluation of soft-tissue structures — a com-parison between 1 T and 1.5 T MRI scanners; (iii) short-term and long-term reproducibility of computer-determined medial minimum jointspace width (mJSW) of the knee using a fixed-flexion X-ray protocol;(iv) determination of ‘normal’ values of minimum medial joint spacewidth of the knee, bone density using dual X-ray absorptiometry aroundthe knee joint and cartilage volume and thickness in men and womenper decade between the ages of 20 and 69 years; (v) determination ofvalues of medial mJSW of the knee, bone density around the knee jointand cartilage volume and thickness in men and women with varyingdegrees of knee osteoarthritis (OA); (vi) development of a longitudinaldatabase of patients with OA of the knee, documenting pain, physicalfunction, quality of life, history, medication use, family history, physicalexamination, blood tests, plain film radiographs and MRI of the kneeusing a 1 T extremity MRI scanner; (vii) development of a more fullyautomated technique for cartilage segmentation of three-dimensional(3D) MRI data; and (viii) quantification of 3D trabecular bone structureusing high-resolution MRI.Methods Healthy volunteers and patients with knee OA referred forassessment to a rheumatologist are invited to participate in the variousstudies. All patients are asked to complete preset questionnaires. Radi-ographs of the knee are performed postero-anteriorly in a standardizedfixed-flexion position by trained technicians. Radiographs are subse-quently digitized and analyzed for mJSW using an automated computeralgorithm. A 1 T extremity MRI scanner is used for imaging each individu-al’s knee. Sequences include a saggital T1-weighted, 3D spoiled gradientecho with fat saturation, a saggital T1-weighted fast spin echo (FSE), acoronal T2-weighted FSE and an axial FSE inversion recovery sequence.Results Quantitative cartilage measurements of normal and OA sub-jects’ knees were obtained using a validated segmentation techniqueon both 1 T and 1.5 T MRI images. The 1 T extremity MRI scanner hasbeen found to be reliable and of comparable precision in comparisonwith a 1.5 T whole-body scanner.The use of a fixed-flexion position and a computer algorithm to deter-mine medial mJSW of the knee in patients having normal orosteoarthritic knees has been found to be reliable in both short-termand long-term studies. Forty-seven pairs of knee radiographs wereassessed in the short-term study while 14 pairs in a long-term studywere assessed. Reliability for both studies was measured by means ofintraclass correlation coefficient and found to be 0.95–0.99 for bothhealthy subjects and those with OA.A cross-sectional study of 45 patients referred for assessment of kneepain is being completed. Data analyses will include comparison of painscales, history and physical examination with MRI findings in the knee.Conclusions Quantitative cartilage measurements using a 1 T office-based extremity MRI scanner have been found to be reliable and ofcomparable precision with those obtained using a 1.5 T whole-bodyMRI scanner. The use of a fixed-flexion radiographic technique forassessing mJSW has been found to be reliable in a long-term repro-ducibility study at our center. Early diagnosis and prompt assessmentsof patients with OA can be accessible using an office-based extremityMRI scanner and could prove to be a valuable clinical tool with thedevelopment of disease-modifying agents for the treatment of OA.Acknowledgements The Arthritis Society and Canadian Institutes ofHealth Research (PB), and the Canadian Arthritis Network (KAB).Available online http://arthritis-research.com/supplements/6/S3

Magnetic resonance imaging, X-ray and dual X-ray absorptiometry techniques for assessment and monitoring of knee osteoarthritis

Amis AA: Measurement of patellar tracking: assessment and analysis of the literature. Clin Orthop

Current concepts review: patellar pain.

DR: Magnetic resonance imaging for in vivo assessment of three-dimensional patellar tracking.

http://dash.harvard.edu/bitstream/handle/1/4789782/Boulos_MagneticResonance.pdf?sequence=1

Magnetic resonance imaging, X-ray and dual X-ray absorptiometry techniques for assessment and monitoring of knee osteoarthritis

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