Hugh Markus discusses genetic factors in stroke risk, and emphasizes the importance of large sample studies and rigorous replication of results in genetic stroke research

A Gschwendtner

A Hassan

A Joutel

A Richards

A Rolfs

AO Edwards

B Rohrer

C Newton-Cheh

D Carmelli

DB Gould

DF Gudbjartsson

DJ Klionsky

E Flossmann

F Fazekas

H Schunkert

Hugh S. Markus

J Hardy

K Hara

K Vahedi

L Jartti

LA Hindorff

LD Atwood

M Dichgans

M Matarín

MA Ikram

MW Lorenz

O Opherk

P Jerrard-Dunne

P Kraft

P Polychronopoulos

R Duggirala

S Bevan

S Gretarsdottir

S Moskau

SE Humphries

ST Turner

Suh-Hang Hank Juo

PLoS Medicine

English

PubMed

Crossref

Unravelling the Genetics of Ischaemic Stroke

Markus Hugh S.

Public Library of Science (PLOS)

Epidemiological studies suggest genetic predisposition is important in stroke risk.

Monogenic conditions are important for the individual patient but do not account for much population attributable risk. An increasing number of such conditions are being described, particularly for the small vessel disease stroke subtype.

The candidate genes approach has proved disappointing in identifying genes contributing to the risk of multifactorial or polygenic stroke. This is a situation shared with other complex diseases.

Recently the GWAS (genome-wide association study) approach has identified genetic loci for many other cardiovascular diseases such as coronary heart disease, diabetes, and hypertension, and is just being applied to stroke. Some novel genetic variants initially associated with other cardiovascular diseases have recently been identified as risk factors in stroke populations

Markus, HS

St George's Online Research Archive

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Unravelling the Genetics of Ischaemic Stroke

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