The SCC is the second most frequent cutaneous malignant neoplasia caused primarily by the chronic and excessive exposure to the ultraviolet radiation. The objective of this work is to discuss the global epidemiologic profile of the SCC through a systematic review. A research was made in PUBMED database using the terms squamous cells skin cancer, epidemiology squamous cells skin cancer, penile squamous cell carcinoma, squamous cell carcinoma of the penis, vulva SCC epidemiology and depletion of ozone layer. Another research was made in SCIENCE DIRECT database using the terms epidemiology of non-melanoma skin cancer, epidemiology of squamous cells carcinoma, squamous cells carcinoma, skin cancer and UV radiation. In the end, 19 articles were related. Only the articles dating from up to 2000 were considered. It was verified in this review that several studies of all continents show increasing numbers of cases, becoming a serious problem of the world public health.O Carcinoma de Células Escamosas (SCC) é a segunda neoplasia maligna cutânea mais freqüente, causada primordialmente pela exposição crônica e excessiva à radiação ultravioleta. O objetivo deste trabalho é discutir o perfil epidemiológico global do SCC através de uma revisão sistemática. Foi realizada uma busca na base de dados PUBMED com a utilização dos termos: squamous cells skin cancer, epidemiology squamous cells skin cancer, penile squamous cell carcinoma, squamous cell carcinoma of the penis, vulva SCC epidemiology e depletion of ozone layer. Outra busca foi realizada na base de dados SCIENCE DIRECT, com os termos: epidemiology of non-melanoma skin cancer, epidemiology of squamous cells carcinoma, squamous cells carcinoma, skin cancer, e, por fim, o termo UV radiation. No total, 19 artigos foram selecionados, sendo considerados aqueles publicados a partir de 2000. A revisão permitiu verificar que estudos em países de todos os continentes mostram um número crescente de casos, o que configura um grave problema de saúde pública mundial
