Carobene, Simon

Cox, Russell J.

Crosby, John

Crump, Matthew P.

Fukuda, Daisuke

Gao, Shu Shan

Han, Li Chen

Hothersall, Joanne

Murphy, Annabel C.

Simpson, Thomas J.

Song, Zhongshu

Thomas, Christopher

Thomas, Christopher M.

Willis, Christine L.

The biosynthesis of the mixed PKS-FAS-NRPS hybrid antibiotic thiomarinol A was investigated using feeding studies to both wild type and mutant strains of the marine bacterium Pseudoalteromonas. Particularly interesting features of the pathway include assembly of the 8-hydroxyoctanoic acid side-chain via chain extension of a C4-precursor (4-hydroxybutyrate), and construction of the pyrrothine unit from cysteine via (HolA-D, F-H) prior to intact incorporation into thiomarinol (catalysed by TmlU). A series of thiomarinol-related and other minor metabolites have been isolated from wild-type and mutant strains. The results of these investigations are rationalised in terms of the overall biosynthetic pathway.</p

Gao, Shu-Shan

Han, Li-Chen

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Biosynthesis of thiomarinol A and related metabolites of Pseudoalteromonas sp SANK 73390

University of Birmingham Research Portal

Biosynthesis of thiomarinol A and related metabolites of Pseudoalteromonas sp. SANK 73390

Annabel C. Murphy

Shu-Shan Gao

Li-Chen Han

Simon Carobene

Daisuke Fukuda

Zhongshu Song

Joanne Hothersall

Russell J. Cox

John Crosby

Matthew P. Crump

Christopher M. Thomas

Christine L. Willis

Thomas J. Simpson

Crossref

Chemical Science

https://research-information.bris.ac.uk/files/87464052/TJS_Thiomarinol_Chem.Sci..pdf

Biosynthesis of thiomarinol A and related metabolites of Pseudoalteromonas sp SANK 73390

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University of Birmingham Research Portal

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University of Birmingham Research Portal