Swallow, Adam P

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                          Swallow, A. P. (2016). Evaluating the effect of maropitant, a neurokinin-1(NK-1) receptor antagonist, on intra-operative anaesthetic requirements andpost-operative nausea and vomiting in dogs undergoing routineovariohysterectomy. Abstract from BSAVA Congress 2016, Birmingham,United Kingdom.Early version, also known as pre-printLink to publication record in Explore Bristol ResearchPDF-documentUniversity of Bristol - Explore Bristol ResearchGeneral rightsThis document is made available in accordance with publisher policies. Please cite only the publishedversion using the reference above. Full terms of use are available:http://www.bristol.ac.uk/pure/about/ebr-terms.htmlImportant notes:  You MUST use this template. If you don’t use it your abstract WILL be rejected.  Do NOT enter author and institution information on this form. You will be able to enter this information online when you submit the abstract.  Do NOT write outside the boxes. Any text or images outside the boxes will be deleted.  Do NOT alter this form by deleting parts of it or adding new boxes. Simply enter your information into the boxes. The form will be automatically processed – if you alter it your submission will not be processed correctly.  Save this file in .doc or .docx format.   385 word limit – if you exceed this limit your abstract will be rejected.  Title: Evaluating the effect of maropitant, a neurokinin-1 (NK-1) receptor antagonist, on intra-operative anaesthetic requirements and post-operative nausea and vomiting in dogs undergoing routine ovariohysterectomy.  Abstract:  (Your abstract must use Normal style and must fit into the box. Do not enter author details) Objectives: To establish if pre-operative maropitant significantly reduced intra-operative isoflurane requirement and reduced clinical signs associated with post-operative nausea and vomiting (PONV) in dogs.   Methods: 24 client-owned dogs presenting for ovariohysterectomy were enrolled into this prospective, double-blinded, randomised clinical trial. Eligible dogs were 0.4-8 years old, ASA grade 1-2 and not pregnant/ displaying signs of pseudocyesis or oestrus. Pre-medication consisted of acepromazine (0.03mg/kg) combined with methadone (0.3mg/kg) intra-muscularly 45 minutes before anaesthetic induction with intravenous propofol, dosed to effect. Meloxicam (0.2mg/kg) was given intravenously following cephalic vein catheterization. Additionally, at premedication, dogs were randomly assigned to receive saline (group S) (0.1ml/kg subcutaneously, n=12) or maropitant (group M) (1mg/kg subcutaneously, n=12). Methadone (0.1mg/kg intravenously) was repeated four hours later. Anaesthesia was maintained with isoflurane in oxygen, dosed to effect (same blinded observer). Monitored patient parameters included heart rate, non-invasive blood pressure, pulse oximetry, temperature, capnography and end-tidal isoflurane concentration (ETIso). Post-operatively, dogs were assessed hourly using the short form of the Glasgow Composite Pain Score (GCPS) and examined for clinical signs attributable to PONV [scored from 0 (none) to 3 (severe)]. A t-test was used to asses mean ETIso. Remaining variables were analyzed using Mann-Whitney U tests. Significance was set at P<0.05.   Results: Mean ±SD ETIso was lower in group M (1.19 ± 0.26%) than group S (1.44 ± 0.23%) (P=0.022). Group M had lower median [range] ETIso first incision (1.02% [0.77-1.8%]) and at 1st ovarian pedicle ligation (1.13% [0.50-1.84%]) than group S (1.45% [0.81-1.9%] and 1.45% [0.69-3.2%]; P=0.03 and P=0.02 respectively). No other cardiorespiratory variables or post-operative GCPS differed significantly between groups. Overall, 50% of dogs displayed signs attributable to PONV, with no significant difference in PONV scores between groups (P=0.198).   Conclusion: Maropitant reduced intra-operative isoflurane requirements, although not consistently and did not significantly affect the incidence of PONV.   

Evaluating the effect of maropitant, a neurokinin-1 (NK-1) receptor antagonist, on intra-operative anaesthetic requirements and post-operative nausea and vomiting in dogs undergoing routine ovariohysterectomy

https://research-information.bris.ac.uk/files/73569284/BSAVA2016_0005_2.pdf

Evaluating the effect of maropitant, a neurokinin-1 (NK-1) receptor antagonist, on intra-operative anaesthetic requirements and post-operative nausea and vomiting in dogs undergoing routine ovariohysterectomy

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