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Complicated intra-abdominal infections worldwide: the definitive data of the CIAOW Study
Authors
A Abbas
AR Adesunkanmi
+81 more
F Agresta
A Ahmed
L Ansaloni
A Attri
G Augustin
M Badiel
G Baiocchi
M Bala
Z Balogh
R. Barnab\ue9
O Ben-Ishay
C Bendinelli
W Biffl
F Catena
F Coccolini
R Coimbra
D Corbella
Y Cui
R D\uedaz-Nieto
K Das
S Di Saverio
T El Zalabany
GP Fraga
I Gerych
W Ghnnam
CA Gomes
RA Gonsaga
G Guercioni
S Gupta
AO Hamedelneel
H Hamid
SK Hong
T Irahara
W Ishii
Y Izawa
J Jarry
E Jovine
J Kenig
I Khan
V Khokha
Y Kluger
Y Kobe
K Koike
KY Kok
V Kong
JG Lee
A Leppaniemi
HA Lohse
V Lohsiriwat
M Malangoni
S Marwah
D Massalou
AC Mefire
EE Moore
K Murata
N Naidoo
K Oka
CA Ordonez
MP Peev
GA Pereira
E Poiasina
M Rangarajan
B Sakakushev
J Sanjuan
M Sartelli
N Sato
R Sharma
T Shoko
B Siribumrungwong
M Skrovina
A Tavares
C Tran\ue0
G Tugnoli
G Velmahos
A Verni
N Vettoretto
I Wani
JF Whelan
KC Yuan
S Zachariah
M Zida
Publication date
1 January 2014
Publisher
'Springer Science and Business Media LLC'
Doi
Cite
Abstract
The CIAOW study (Complicated intra-abdominal infections worldwide observational study) is a multicenter observational study underwent in 68 medical institutions worldwide during a six-month study period (October 2012-March 2013). The study included patients older than 18 years undergoing surgery or interventional drainage to address complicated intra-abdominal infections (IAIs).1898 patients with a mean age of 51.6 years (range 18-99) were enrolled in the study. 777 patients (41%) were women and 1,121 (59%) were men. Among these patients, 1,645 (86.7%) were affected by community-acquired IAIs while the remaining 253 (13.3%) suffered from healthcare-associated infections. Intraperitoneal specimens were collected from 1,190 (62.7%) of the enrolled patients.827 patients (43.6%) were affected by generalized peritonitis while 1071 (56.4%) suffered from localized peritonitis or abscesses.The overall mortality rate was 10.5% (199/1898).According to stepwise multivariate analysis (PR = 0.005 and PE = 0.001), several criteria were found to be independent variables predictive of mortality, including patient age (OR = 1.1; 95%CI = 1.0-1.1; p < 0.0001), the presence of small bowel perforation (OR = 2.8; 95%CI = 1.5-5.3; p < 0.0001), a delayed initial intervention (a delay exceeding 24 hours) (OR = 1.8; 95%CI = 1.5-3.7; p < 0.0001), ICU admission (OR = 5.9; 95%CI = 3.6-9.5; p < 0.0001) and patient immunosuppression (OR = 3.8; 95%CI = 2.1-6.7; p < 0.0001). © 2014 Sartelli et al.; licensee BioMed Central Ltd
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Archivio della Ricerca - Università di Pisa
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Archivio istituzionale della ricerca - Università dell'Insubria
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Last time updated on 10/04/2020