Racial/ethnic differences in hepatic steatosis in a population‐based cohort of post‐menopausal women: the Michigan Study of Women's Health Across the Nation
Aims The prevalence of hepatic steatosis may differ between post‐menopausal African‐American women and non‐Hispanic white women and by sex hormone binding globulin level. We examined prevalence of hepatic steatosis by race/ethnicity and associations with sex hormone binding globulin. Methods Participants included post‐menopausal women who underwent hepatic ultrasound ( n = 345) at the Michigan site of the Study of Women's Health Across the Nation, a population‐based study. We examined hepatic steatosis prevalence by race/ethnicity and used logistic regression models to calculate the odds of hepatic steatosis with race/ethnicity and sex hormone binding globulin, after adjustment for age, alcohol use, waist circumference, high density lipoprotein cholesterol, triglycerides, systolic blood pressure and use of medications reported to lower intrahepatic fat. Results Fewer African‐American women than non‐Hispanic white women had hepatic steatosis (23 vs. 36%, P = 0.01). African‐American women had lower triglyceride and low‐density lipoprotein cholesterol levels, but higher blood pressure and follicle‐stimulating hormone levels ( P < 0.05). In the optimal‐fitting multivariable models, women in the highest tertile of sex hormone binding globulin (60.2–220.3 nmol/l) had a lower odds of hepatic steatosis (odds ratio 0.43, 95% CI 0.20–0.93) compared with women in the lowest tertile of sex hormone binding globulin (10.5–40.3 nmol/l). There was an interaction between race/ethnicity and medication use whereby non‐Hispanic white women using medications had three times higher odds of hepatic steatosis compared with African‐American women not using medications (odds ratio 3.36, 95% CI 1.07–10.58). Interactions between race/ethnicity and other variables, including sex hormone levels, were not significant. Conclusions Hepatic steatosis on ultrasound may be more common in post‐menopausal non‐Hispanic white women than African‐American women and was associated with lower levels of sex hormone binding globulin. What's new? Although hepatic steatosis is common in post‐menopausal women, previous studies have not examined risk factors in this population, particularly sex steroids and sex hormone binding globulin. We report that increased sex hormone binding globulin, the primary binding protein of sex hormones and a risk factor for diabetes, was strongly associated with decreased odds of hepatic steatosis in both race/ethnicities.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/101792/1/dme12225.pd
