Purpose Association of ESR1 gene PvuII, XbaI and (TA)n
microsatellite polymorphisms and woman infertility was
evaluated.
Methods Infertile(n=104) and fertile(n=107) women were
included in this study. We performed polymerase chain
reaction-restriction fragment-length polymorphism analysis
for detecting ESR1 polymorphisms.
Result(s) PvuII and XbaI polymorphisms confered risk for
infertility in a simple dominant manner in which a
significant relationship was observed between infertile and
control women. Infertile women had fewer(<18) short
repeat alleles in promotor region. ESR1 genotypes were
compared concerning maturation, fertilization, pregnancy
rates and embryo quality. Although no difference was found in
terms of pregnancy rates, maturation and fertilization rates
were significantly smaller in pp and xx genotypes. Also, pp
genotypes had significantly lower number of good quality
embryos. Long TA repeat in promotor was found to be
associated with low fertilization rate.
Conclusion(s) Polymorphisms at the ESR1 gene are associated
with infertility in this Turkish infertile women
population