Motivation: Cancer is an evolutionary process characterized by accumulating mutations. However, the precise timing and the order of genetic alterations that drive tumor progression remain enigmatic

Baudis

Beerenwinkel

Brodeur

Buerger

Desper

Fearon

Gnarra

H. Moch

Hanahan

Heydebreck

Hjelm

Hoglund

H  glund

Jiang

Kirkpatrick

M. Baudis

M. Gerstung

N. Beerenwinkel

Roylance

Tibshirani

English

PubMed

Crossref

Quantifying cancer progression with conjunctive Bayesian networks

Gerstung, Moritz

Baudis, Michael

Moch, Holger

Beerenwinkel, Niko

Repository for Publications and Research Data

MOTIVATION: Cancer is an evolutionary process characterized by accumulating mutations. However, the precise timing and the order of genetic alterations that drive tumor progression remain enigmatic. RESULTS: We present a specific probabilistic graphical model for the accumulation of mutations and their interdependencies. The Bayesian network models cancer progression by an explicit unobservable accumulation process in time that is separated from the observable but error-prone detection of mutations. Model parameters are estimated by an Expectation-Maximization algorithm and the underlying interaction graph is obtained by a simulated annealing procedure. Applying this method to cytogenetic data for different cancer types, we find multiple complex oncogenetic pathways deviating substantially from simplified models, such as linear pathways or trees. We further demonstrate how the inferred progression dynamics can be used to improve genetics-based survival predictions which could support diagnostics and prognosis. AVAILABILITY: The software package ct-cbn is available under a GPL license on the web site cbg.ethz.ch/software/ct-cbn CONTACT: moritz.gerstung@bsse.ethz.ch

Gerstung, M

Moch, H

Beerenwinkel, N

ZORA

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http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2781752

Quantifying cancer progression with conjunctive Bayesian networks

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