International Journal of Chemical and Pharmaceutical Sciences
Abstract
A series of 3-(pyridin-3-yloxymethyl)-chromen-2-ones were synthesized by the reaction of substituted 4-bromomethylcoumarins with 3-hydroxypyridines. The synthesized compds. were screened for their cytotoxic activities against Dalton's ascitic lymphoma (DAL) and Ehrlich ascites carcinoma (EAC) cell lines. The 2-(2-Methyl-pyridin-3-yloxymethyl)-benzo[f]chromen-3-one was found to be the most cytotoxic against DAL cell line and 6-Isopropyl-3-(2-methyl-pyridin-3-yloxymethyl)-chromen-2-one was found to be the most cytotoxic against EAC cell line
