A facile and highly efficient method for the regioselective one-pot synthesis of a series of novel 1-(substituted phenyl)-2-(4-(trimethylsilyl)-1H-1,2,3-triazol-1-yl)ketones from 2-bromo-1-(substituted phenyl)ketones, sodium azide, and trimethylsilyl acetylene, through Cu (I) catalyzed 1,3-dipolar [3+2] cycloaddn. reaction is reported. The reaction proceeds smoothly in 40% aq. acetone at room temp. without the use of any additive. Regioselectivity privileges the formation of the corresponding C-4 silylated-1,2,3-triazoles in high yields in all instances. The methodol. offers an entry to new 1,2,3-triazolyl-4-trimethylsilyl anionic synthon scaffolds
