In vitro antimicrobial activity and DNA cleavage studies: synthesis and characterization of novel M(II) complexes with tridentate [ONO] donor Schiff base ligand derived from phenylpropane hydrazide

Abstract

Three new ternary complexes of general formulation [M(L)​n] (1-​3)​, where L = N'-​(5-​chloro-​2-​hydroxybenzylidine)​-​3-​phenylpropane hydrazide; n = 2; M = Cu, Ni, Zn, complexes are synthesized, characterized by various physicochem. and UV-​Vis, FT-​IR, 1H NMR and ESI-​MS spectroscopic methods. The Cyclic voltammetry show a quasi-​reversible cyclic voltammetric response due to one electron Cu(II)​/Cu(I) redn. near 100 mV (vs. SCE) in DMF-​0.1 M KCl. All the compds. were screened for their in-​vitro antibacterial activity against Gram pos. and Gram neg. bacterial strains. Among them, Cu complex showed good activity against all microbes. The copper complex shows moderate chem. nuclease activity in the presence of MPA as a reducing agent