Synthesis of peptidyl ureas using p-​nitrophenyl (9-​fluorenylmethoxycarbonylamino)​methylcarbamate derivatives

Babu Vommina V Suresh, .; Patil Basanagoud, S.; Vasanthakumar Ganga-Ramu, .

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Synthesis of peptidyl ureas using p-nitrophenyl (9-fluorenylmethoxycarbonylamino)methylcarbamate derivatives

Authors: . Babu Vommina V Suresh
S. Patil Basanagoud
. Vasanthakumar Ganga-Ramu
Publication date: 1 January 2004
Publisher: 'Informa UK Limited'
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Abstract

Carbamates Fmoc-NHCHRNHCO2C6H4NO2-p (Fmoc is 9-fluorenylmethoxycarbonyl, R is an amino acid side chain) were prepd. using isocyanates derived from Fmoc-amino acid azides and p-nitrophenol in the presence of an equimolar quantity of N-ethyldiisopropylamine. The carbamates were coupled with amino acid ester hydrochlorides to afford dipeptidyl ureas