The investigation was aimed to evaluate the antifungal and antifumonisin activities of budmunchiamine A and pithecolobine against Fusarium verticillioides. The budmunchiamine A was isolated from Albizia amara and pithecolobine from Albizia saman. The results demonstrated that both budmunchiamine A and pithecolobine significantly inhibited the growth and fumonisin B1 production by F. verticillioides in a dose dependent manner. The MIC and MFC values ranged from 0.125 to 0.25 mg/ml and 0.25 to 0.5 mg/ml, respectively. In vitro evaluation showed that the fumonisin B1 production was completely inhibited by budmunchiamine A and pithecolobine at 0.25 mg/ml and 0.5 mg/ml, while in vivo evaluation showed complete inhibition at 0.25 g/kg and 0.5 g/kg, respectively. The present findings indicate the possible use of budmunchiamine A and pithecolobine as alternative agents to control the fungal and mycotoxin contaminations in food grains
