In the present study, salicylic acid and anthranilic acid were modified as lipids palmitoylsalicylic acid (PSA) and N-palmitoylanthranilic acid (N-PAA) by a simple esterification/amidation reaction of the resp. acid with palmitoyl chloride. On screening for the pharmacol. activity, PSA exhibited potent and persistent analgesic and antiinflammatory effects, while N-PAA, demonstrated novel analgesic and antipyretic effects
