Calmodulin-binding (CAM-binding) proteins are one of the most recently studied cases of protein interactions. Calmodulin is a calcium-binding protein that is a major transducer of calcium signal that forms an intricate network of loops to control the location, amount and e ect of calcium in ux. CAM-binding proteins are a varied group of targets and their interactions with Calmodulin can be subdivided into calcium-independent and calcium dependent ways of binding and regulation