Signaling complexes typically consist of highly dynamic molecular ensembles that are challenging to study and to describe accurately. Conventional mechanical descriptions misrepresent this reality and can be actively counterproductive by misdirecting us away from investigating critical issues

Blinov, Michael L

Loew, Leslie M

Mayer, Bruce J

English

PubMed

Bruce J Mayer

Michael L Blinov

Leslie M Loew

Crossref

Molecular machines or pleiomorphic ensembles: signaling complexes revisited

A quantitative protein interaction network for the ErbB receptors using protein microarrays. Nature

Birtwistle JB, Kholodenko BN: Ligand-dependent responses of the ErbB signaling network: experimental and modeling

BJ, Lim WA: Domains, motifs, and scaffolds: the role of modular interactions in the evolution and wiring of cell signaling

Blinov

Dikic I, Zhou MM, Pawson T: Reading protein modifications with interaction domains. Nat

Garcia combinatorial modification of histone H3 in human cells. Nat Methods

Gibson TJ: Cell regulation: determined to signal discrete

Hlavacek WS, Faeder JR, Blinov ML, Posner RG, Hucka M, Fontana W: Rules for modeling signal-transduction systems. Sci STKE 2006, 2006:re6.

Huang B, Bates M, Zhuang X: Super-resolution fluorescence microscopy. Annu Rev Biochem 2009, 78:993-1016. Published: 16 October 2009 doi:10.1186/jbiol185 © 2009 BioMed Central Ltd

Hucka M, Finney A, Sauro HM, Bolouri H, Doyle JC, Kitano H,

L, Courtot M, Dogrusoz U, Freeman Funahashi

Liss M, Wagner R, Saksela K: Identification of preferred protein interactions by phage-display of the human Src

Mass spectrometry identifies and quantifies 74 unique histone H4 isoforms in differentiating human embryonic stem cells. Proc Natl Acad Sci USA

Mayer BJ: SH3

Morgan F, Lakshminarayana A, Gao F, Li Y, Loew LM: Virtual Cell modelling and simulation software environment. IET Syst Biol 2008, 2:352-362.

P, Sidhu S, Boone C: Bayesian modeling of the yeast SH3 domain interactome predicts spatiotemporal dynamics of

RNA virus mutations and fitness for survival. Annu Rev Microbiol

Sci 2008, 366:3017-3043.

Specificity in signal transduction: from phosphotyrosine-SH2 domain interactions to complex cellular systems. Cell

The human and mouse complement of SH2 domain proteins - establishing the boundaries of phosphotyrosine signaling. Mol Cell

Westermark B: Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev

Whitty A:

Zarrinpar A, Park SH, Lim WA: Optimization of specificity in a cellular protein interaction network

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2776906

Molecular machines or pleiomorphic ensembles: signaling complexes revisited

Abstract

Similar works

Full text

Available Versions

Crossref