Development of vaccines against peste des petits ruminants: CIRAD's achievements and future challenges

Abstract

CIRAD, France, in collaboration with the Pirbright Institute, United Kingdom, was the first laboratory to develop a live attenuated vaccine against peste des petits ruminants (PPR). This vaccine available in the 1980s was shown to provide a life-long immunity after a single injection [5] and is now widely used in sheep and goats. New vaccines are in development, more specifically thermotolerant vaccines for use in tropical conditions and DIVA (differentiating infected from vaccinated animals) vaccines to gain virus-free status more easily and rapidly. This paper reviews most of the current and recently developed vaccines at CIRAD and emphasises their adequate delivery and utilisation in the field, for successfully decreasing the incidence of PPR. (Résumé d'auteur