This work was supported by the Spanish Ministry of Economy and Competiveness and the Carlos III Health Institute through CIBERSAM, and the Foundation Santander-UCM (GR 58/08), and partly supported by the Spanish Ministry of Economy and Competiveness directly, and by the European Regional Development Fund, FEDER (PI10/01746, PI11/01977, PI11/02708,PI12/02077), local grants from the Department of Education, Linguistic Policy and Culture of the Basque Country Government (2010111170, 2010112009), the Basque Foundation for Health Innovation and Research (BIOEF), ) and the University of the Basque Country (GIC10/80, GIC12/84).Martinez-Cengotitabengoa, M., Macdowell, K.S., Alberich, S., Diaz, F.J., Garcia-Bueno, B., Rodriguez-Jimenez, R., Bioque, M., Berrocoso, E., Parellada, M., Lobo, A., Saiz, P.A., Matute, C., Bernardo, M., Gonzalez-Pinto, A., Leza, J.C
