In a commentary on two new research studies in PLoS Medicine, Leonard Kritharides discusses the role of inflammatory markers in predicting cardiovascular outcomes and patients' responses to treatment

A Tedgui

B Zethelius

BJ Ridker PM

HJ Audebert

J Danesh

Leonard Kritharides

M Di Napoli

MS Sabatine

N Sattar

NR Cook

PM Ridker

W Whiteley

English

PubMed

Kritharides Leonard

Public Library of Science (PLOS)

Inflammatory Markers and Outcomes in Cardiovascular Disease

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In a prospective cohort study of patient outcomes following stroke, William Whiteley and colleagues find that markers of inflammatory response are associated with poor outcomes. However, addition of these markers to existing prognostic models does not improve outcome prediction

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PLoS Medicine

Inflammatory markers and outcomes in cardiovascular disease.

C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease.

C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14719 initially healthy American women.

Cytokines in atherosclerosis: Pathogenic and regulatory pathways.

Evaluation of C-reactive protein measurement for assessing the risk and prognosis in ischemic stroke: a statement for health care professionals from the CRP Pooling Project members.

Inflammatory markers and poor outcome after stroke: A prospective cohort study and systematic review of interleukin 6. PLoS Med 6(8):

Prognostic significance of the Centers for Disease Control/ American Heart Association high-sensitivity C-reactive protein cut points for cardiovascular and other outcomes in patients with stable coronary artery disease.

Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.

Systemic inflammatory response depends on initial stroke severity but is attenuated by successful thrombolysis.

Use and misuse of the receiver operating characteristic curve in risk prediction.

Use of multiple biomarkers to improve the prediction of death from cardiovascular causes.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2730031

Inflammatory Markers and Outcomes in Cardiovascular Disease

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Public Library of Science (PLOS)

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Directory of Open Access Journals

Public Library of Science (PLOS)