A 54-year-old man was referred to our department for colorectal cancer screening. The colonoscopy revealed, at the ascending colon, several white plaques, some confluent, interspersed with normal mucosa (Fig. 1). Biopsies were performed and the histopathological examination showed a fragment of polypoid colonic mucosa with optically empty vacuoles in the lamina propria (Fig. 2) and irregular cystic spaces of varying sizes, similar to adipocytes in the absence of inflammation or dysplasia. Colonic pseudolipomatosis is a benign and rare condition, with an estimated prevalence of 0.02-0.3 % in colonoscopic series, characterized by the presence of vacuoles with gas content in the lamina propria of the large intestine [1]. The incidence is more frequent between the sixth and seventh decade of life [2]. The pathogenesis remains unclear
