The aim of this study was to evaluate the inhibitory activity of 7-hydroxycalamenene-rich essential oil nanoemulsion against filamentous fungi and yeasts

ALMEIDA, C. A.

ALVIANO, C. S.

ALVIANO, D. S.

AZEVEDO, M. M. B. de

BIZZO, H. R.

CHAVES, F. C. M.

RICCI JÚNIOR, E.

SILVA, M. B. F. C. da

English

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846  Micologia Médica - Antifúngicos  ANTIFUNGAL ACTIVITY OF 7-HYDROXYCALAMENENE-RICH ESSENTIAL OIL NANOEMULSION  Mariana Maria Barros de Azevedo1; Catia Amancio Almeida1; Maria Bárbara Faria Cardoso da Silva1; Francisco Celio Maia Chaves2; Eduardo Ricci Júnior1; Humberto Ribeiro Bizzo3; Daniela Sales Alviano1; Celuta Sales Alviano1. E-mail: marimbarros@gmail.com  (1)Federal University of Rio de Janeiro - Rio de Janeiro, Brazil; (2)EMBRAPA Western Amazon - Amazon, Brazil; (3)EMBRAPA Food Technology - Rio de Janeiro, Brazil   RESUMO Nanoemulsions, unlinke microemulsions, are metastable submicron oil-in-water dispersions with droplet diameter in the range of 10-100 nm.  Potential advantages of nanoemulsions over conventional emulsions like high physical stability, can be sterilised by filtration, high bioavailability and low turbidity make them attractive systems for application in food, cosmetics and pharmaceutical industry. Nanoemulsions serve as delivery agents for lipophilic bioactive compounds such as drug in the pharmaceutical industry and, for flavors and antimicrobial agents in the food industry, for solubilizing water-insoluble pesticides in agrochemical industry and as vehicle for skincare and personal products in cosmetics. The leaves from Croton cajucara Benth. (family Euphorbiaceae), a shrub from the Amazon, have been locally used in folk medicine to treat diabetes, malaria, gastrointestinal and liver disorders. A chemotype of this species was found with an essential oil rich in 7-hydroxycalamenene. 7-hydroxycalamenene is a hydroxylated sesquiterpene of molecular weight 218 g/mol found in Heritiera ornithocephala, Eremophila drummondii, Heteroscyphus planus, Tilia europea, Morus alba, Ulmus thomasii and other elm species, and methanolic and dichloromethanic extracts of Bazzania trilobata. This substance is reported to have antifungal activity against Botrytis cinerea, Cladosporium cucumerinum, Phythophthora infestans, Pyricularia oryzae and Septoria tritici. The aim of this study was to evaluate the inhibitory activity of 7-hydroxycalamenene-rich essential oil nanoemulsion against filamentous fungi and yeasts. Minimum inhibitory concentration (MIC) was evaluated in triplicate according standard methods from Clinical and Laboratory Standards Institute (CLSI) M27-A2 and M38-A2. All species tested were sensitive to nanoemulsion at concentrations ranging from 12.21 μg/mL for Absidia cylindospora, Mucor ramosissimus and Syncephalastrum racemosum, to 6578.95 μg/mL for Candida dubliniensis, C. famata, C. tropicalis and C. glabrata. These results suggest a possible antifungal potential of 7-hydroxycalamenene-rich essential oil nanoemulsion formulation against tested fungi, although further tests are necessary.   APOIO Financial support: FAPERJ, CNPq and CAPES.    

Antifungal activity of 7-hydroxycalamenene-rich essential oil nanoemulsion.

http://www.alice.cnptia.embrapa.br/bitstream/doc/1060004/1/antifungal.pdf

Antifungal activity of 7-hydroxycalamenene-rich essential oil nanoemulsion.

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