MOLECULAR ANALYSIS OF CHEMOKINE RECEPTOR TYPE 5 (CCR5) CODING REGIONS IN HIV-1\AIDS SUDANESE PATIENTS
- Publication date
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- uofk
Abstract
Chemokine receptors are a subclass of seven transmembrane Gprotein
coupled receptors, a number of which act as co-receptors with CD4 for HIV1
infection, different polymorphisms within chemokine receptor genes were found to
associate with susceptibility to HIV-1 infection and its progression. Analysis of CCR5
for genetic variants in different populations has identified several rare alleles,
however most detected polymorphisms in the CC- chemokine receptor 5 (CCR5) gene
were specific to different populations