Enteric shell-core microparticles, based on
polyelectrolyte complexes between the natural
biopolymer sodium alginate and the (meth)acrylate
copolymers Eudragit®, were produced to encapsulate the
gastrolesive drug indomethacin. The complexation of
polyelectrolytes together with the ultrasonic atomization,
used to produce fine droplets based on alginate ingredient,
can be performed using mild conditions, aqueous
solutions, in absence of organic solvents and chemical
crosslinkers, therefore this approach proves to be
convenient if compared to traditional method
