Multiple wild rodent species can serve as amplifying reservoir hosts for virus subtype IE

Aguirre

Amelia P. Travassos da Rosa

Boakye

Bowen

Brault

Bronze

Carrara

Coffey

Cupp

Eleanor R. Deardorff

Estrada-Franco

Galindo

Jose G. Estrada-Franco

Naomi L. Forrester

Oberste

Robert B. Tesh

Roberto Navarro-Lopez

Scherer

Scott C. Weaver

Smith

Sudia

Turell

Weaver

Young

Emerging Infectious Diseases

English

PubMed

Crossref

Experimental Infection of Potential Reservoir Hosts with Venezuelan Equine Encephalitis Virus, Mexico

In 1993, an outbreak of encephalitis among 125 affected equids in coastal Chiapas, Mexico, resulted in a 50% case-fatality rate. The outbreak was attributed to Venezuelan equine encephalitis virus (VEEV) subtype IE, not previously associated with equine disease and death. To better understand the ecology of this VEEV strain in Chiapas, we experimentally infected 5 species of wild rodents and evaluated their competence as reservoir and amplifying hosts. Rodents from 1 species (Baiomys musculus) showed signs of disease and died by day 8 postinoculation. Rodents from the 4 other species (Liomys salvini, Oligoryzomys fulvescens, Oryzomys couesi, and Sigmodon hispidus) became viremic but survived and developed neutralizing antibodies, indicating that multiple species may contribute to VEEV maintenance. By infecting numerous rodent species and producing adequate viremia, VEEV may increase its chances of long-term persistence in nature and could increase risk for establishment in disease-endemic areas and amplification outside the disease-endemic range

Nikos Vasilakis

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Experimental Infection of Potential Reservoir Hosts with Venezuelan Equine Encephalitis Virus, Mexico

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