Nuclear data uncertainties and their impact on a very wide range of reactor systems, including their associated fuel cycles, have to be assessed in order to consolidate preliminary design studies for new innovative systems. One specific class of systems is the so-called “dedicated waste transmuters”, that are fast neutron systems (critical or sub-critical, i.e. ADS), loaded with a Minor Actinide (MA) dominated fuel and potentially uranium-free. The availability of very general tools for sensitivity and uncertainty analysis together with new variance-covariance matrix data, produced in a joint effort under the auspices of the OECD-NEA by the world leading nuclear data evaluation groups, makes that endeavor particularly significant. In this report major results of interest for dedicated ADS are discussed and the most important fields and data types are pointed out, where priority improvements are required
