It is not well established whether haemorheological alterations
constitute independent risk factors for deep vein thrombosis
(DVT).We have determined in 149 DVT patients and in 185 control
subjects the body mass index (BMI), the haemorheological
profile: blood viscosity (BV), plasma viscosity (PV), fibrinogen
(Fg), erythrocyte aggregation (EA), erythrocyte deformability
(ED) and plasma lipids. In the crude analysis BMI, Fg, PV, EA, triglycerides
(TG) and ApoB were statistically higher and HDL cholesterol
(HDL-Chol) statistically lower in DVT patients than in
controls. No differences in BV and ED were observed.After BMI
adjustment, Fg, PV and EA remained statistically higher in DVT
cases than in controls (P=0.013; P=0.012; P=0.013; P=0.028, respectively).
When the risk of DVT associated with these variables (using cut-offs that corresponded to the mean plus one SD
of the control group) was estimated, EA>8.2 and PV>1.28 mPa.s
were significantly associated with DVT even further adjustment
for lipids and obesity (OR=2.78, P=0.004; OR=1.91, P=0.024, respectively).
However, PV did not remain statistically significant
after additional adjustment for Fg.When we consider together
all the analyzed variables in order to control every variable for
each other,TG>175 mg/dl (OR=3,2,P=0.004) and BMI>30 kg/m2
(OR=3.5, P=0.003), were also independently associated with a
greater risk of DVT. Our results suggest that increased EA constitute
an independent risk factor for DVT. However, when associated
to hyperlipidaemia and obesity it further increases
thrombotic [email protected]
