Compounding pharmacies should be required to follow good manufacturing practices, including end-product sterility testing

Adams

American Society of Health-System Pharmacists

Andrew Lee

Arjun Srinivasan

Candy

Centers for Disease Control and Prevention

Civen

Edina Avdic

Francesca J. Torriani

Harteker

Held

Hsueh

Karen C. Carroll

Kastango

Kilic

Lemaitre

Lisa L. Maragakis

Morris

Patel

Pegues

Perola

Perz

Romanee Chaiwarith

Schweitzer

Sunenshine

Tenover

Tracy R. Ross

Trish M. Perl

Wood

Emerging Infectious Diseases

English

PubMed

Crossref

Sphingomonas

Nationally distributed medications from compounding pharmacies, which typically adhere to less stringent quality-control standards than pharmaceutical manufacturers, can lead to multistate outbreaks. We investigated a cluster of 6 patients in a Maryland hospital who had Sphingomonas paucimobilis bloodstream infections in November 2007. Of the 6 case-patients, 5 (83%) had received intravenous fentanyl within 48 hours before bacteremia developed. Cultures of unopened samples of fentanyl grew S. paucimobilis; the pulsed-field gel electrophoresis pattern was indistinguishable from that of the isolates of 5 case-patients. The contaminated fentanyl lot had been prepared at a compounding pharmacy and distributed to 4 states. Subsequently, in California, S. paucimobilis bacteremia was diagnosed for 2 patients who had received intravenous fentanyl from the same compounding pharmacy. These pharmacies should adopt more stringent quality-control measures, including prerelease product testing, when compounding and distributing large quantities of sterile preparations

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http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2660711

Sphingomonas paucimobilis Bloodstream Infections Associated with Contaminated Intravenous Fentanyl1

Sphingomonas paucimobilis Bloodstream Infections Associated with Contaminated Intravenous Fentanyl1

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