Berkowitz, O.

Buswell, W.

Colot, V.

Furci, L.

Jain, R.

Johannes, F.

Lopez, A.

Pardo, D.

Petriacq, P.

Schwarzenbacher, R.

Ton, J.

White Rose Research Online

Onset and maintenance of plant immune priming

This is a repository copy of Onset and maintenance of plant immune priming.White Rose Research Online URL for this paper:http://eprints.whiterose.ac.uk/137291/Version: Accepted VersionProceedings Paper:Schwarzenbacher, R., Furci, L., Buswell, W. et al. (8 more authors) (2018) Onset and maintenance of plant immune priming. In: FEBS Open Bio. 43rd FEBS Congress, 07-12 Jul 2018, Prague, Czech Republic. Wiley Open Access , p. 16. https://doi.org/10.1002/2211-5463.12449© 2018 The Authors / FEBS. This is an author produced version of a paper subsequently published in FEBS Open Bio. Uploaded in accordance with the publisher's self-archiving policy.eprints@whiterose.ac.ukhttps://eprints.whiterose.ac.uk/Reuse This article is distributed under the terms of the Creative Commons Attribution (CC BY) licence. This licence allows you to distribute, remix, tweak, and build upon the work, even commercially, as long as you credit the authors for the original work. More information and the full terms of the licence here: https://creativecommons.org/licenses/ Takedown If you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing eprints@whiterose.ac.uk including the URL of the record and the reason for the withdrawal request.   Onset and maintenance of plant immune priming  Schwarzenbacher, R, Furci, L, Stassen J, Lopez A, Jain, R, Pardo D, Berkowitz, O., Colot, V., Johannes, F, Petriacq P, and Ton J.  1 P3 Institute for Translational Plant and Soil Biology. Department of Animal and Plant Sciences, The University of Sheffield, UK. 3 La Trobe University, AgriBio/ARC Centre of Excellence in Plant Energy Biology, Australia   3 Institut de Biologie de l'Ecole Normale Supérieure (IBENS), Paris, France 4Technical University of Munich, Munich, Germany.    Plants can increase the responsiveness of their immune system after perception of specific environmental signals. This priming of immunity provides broad-spectrum resistance against pests and diseases. Our previous discovery of the IBI1 receptor of the chemical priming agent beta-aminobutyric acid (BABA) has allowed us to study the molecular mechanisms controlling the onset of immune priming in Arabidopsis. Using this system, we found that VOZ transcription factors physically interact with the IBI1 receptor after pathogen attack, mediating SA-independent priming of cell wall through interaction with ABA-dependent signalling pathways. This work also led to the discovery of a structural BABA analogue, R-beta-homoserine (RBH), which primes distinct defence pathways against biotrophic and necrotrophic pathogens, but is less toxic to plant metabolism than BABA. In parallel, we are studying the epigenetic mechanisms controlling long-lasting immune priming, which stems from our previous discovery that diseased Arabidopsis produces epigenetically primed progeny. Characterization of Arabidopsis mutants that are altered in genome-wide DNA (de)methylation revealed that nearly half of the defence-related transcriptome is directly or indirectly controlled by DNA (de)methylation. Further investigation of the transgenerational effects of disease on DNA methylation indicated global impacts on gene body DNA methylation. Finally, we are mapping and characterizing epigenetic quantitative trait loci (epiQTLs), using a fully characterized mapping population of Arabidopsis epigenetic recombinant inbred lines (epiRILs). Transcriptome analysis of the immune response in a selection of resistant epiRILs points towards a trans-regulatory role of stress-responsive transposable elements in transgenerational immune priming. 

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Onset and maintenance of plant immune priming

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