Correction to Richard J Bloomer, Kelsey H Fisher-Wellman, Kelley G Hammond, Brian K Schilling, Adrianna A Weber and Bradford J Cole: Dietary supplement increases plasma norepinephrine, lipolysis, and metabolic rate in resistance trained men. Journal of the International Society of Sports Nutrition 2009, 6: 

A Fugh-Berman

A Morales

Adrianna A Weber

Bradford J Cole

Brian K Schilling

C Carpéné

C Gonzalez-Yanes

CT Dourish

DM Roffey

DW Wray

EC Petrie

G Fisone

HJ Hapke

IA Paterson

J Galitzky

J Hoffman

J Jitomir

JC Pruessner

JW Lenders

Kelley G Hammond

Kelsey H Fisher-Wellman

KJ Acheson

LA Consitt

MK Caruso

P Barbe

P Valet

RE Duncan

Richard J Bloomer

RK Berge

RW Butcher

S Collins

SS Taylor

TE Graham

VE Crowley

Journal of the International Society of Sports Nutrition

English

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Bloomer, Richard

Fisher-Wellman, Kelley

Hammond, Kelley

Schilling, Brian

Weber, Adrianna

Cole, Bradford

University of Nevada, Las Vegas Repository

Kinesiology and Nutrition Sciences FacultyPublications Kinesiology and Nutrition Sciences4-17-2009Dietary Supplement Increases PlasmaNorepinephrine, Lipolysis, and Metabolic Rate inResistance Trained MenRichard BloomerKelley Fisher-WellmanKelley HammondBrian SchillingUniversity of Nevada, Las Vegas, brian.schilling@unlv.eduAdrianna WeberSee next page for additional authorsFollow this and additional works at: http://digitalscholarship.unlv.edu/kns_fac_articlesPart of the Pharmacy and Pharmaceutical Sciences Commons, and the Sports SciencesCommonsThis Article is brought to you for free and open access by the Kinesiology and Nutrition Sciences at Digital Scholarship@UNLV. It has been acceptedfor inclusion in Kinesiology and Nutrition Sciences Faculty Publications by an authorized administrator of Digital Scholarship@UNLV. For moreinformation, please contact digitalscholarship@unlv.edu.Citation InformationBloomer, R., Fisher-Wellman, K., Hammond, K., Schilling, B., Weber, A., Cole, B. (2009). Dietary Supplement Increases PlasmaNorepinephrine, Lipolysis, and Metabolic Rate in Resistance Trained Men. Journal of the International Society of Sports Nutrition, 6(10),1-2.http://digitalscholarship.unlv.edu/kns_fac_articles/37AuthorsRichard Bloomer, Kelley Fisher-Wellman, Kelley Hammond, Brian Schilling, Adrianna Weber, and BradfordColeThis article is available at Digital Scholarship@UNLV: http://digitalscholarship.unlv.edu/kns_fac_articles/37BioMed CentralPage 1 of 2(page number not for citation purposes)Journal of the International Society of Sports NutritionOpen AccessCorrectionDietary supplement increases plasma norepinephrine, lipolysis, and metabolic rate in resistance trained menRichard J Bloomer*, Kelsey H Fisher-Wellman, Kelley G Hammond, Brian K Schilling, Adrianna A Weber and Bradford J ColeAddress: Department of Health and Sport Sciences, University of Memphis, Memphis, TN, USAEmail: Richard J Bloomer* - rbloomer@memphis.edu; Kelsey H Fisher-Wellman - kfshrwll@memphis.edu; Kelley G Hammond - kghmmond@memphis.edu; Brian K Schilling - bschllng@memphis.edu; Adrianna A Weber - aaweber@memphis.edu; Bradford J Cole - dr.bradfordcole@cptg.net* Corresponding author    AbstractCorrection to Richard J Bloomer, Kelsey H Fisher-Wellman, Kelley G Hammond, Brian K Schilling,Adrianna A Weber and Bradford J Cole: Dietary supplement increases plasma norepinephrine,lipolysis, and metabolic rate in resistance trained men. Journal of the International Society of SportsNutrition 2009, 6: 4Published: 17 April 2009Journal of the International Society of Sports Nutrition 2009, 6:10 doi:10.1186/1550-2783-6-10Received: 7 April 2009Accepted: 17 April 2009This article is available from: http://www.jissn.com/content/6/1/10© 2009 Bloomer et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Publish with BioMed Central   and  every scientist can read your work free of charge"BioMed Central will be the most significant development for disseminating the results of biomedical research in our lifetime."Sir Paul Nurse, Cancer Research UKYour research papers will be:available free of charge to the entire biomedical communitypeer reviewed and published immediately upon acceptancecited in PubMed and archived on PubMed Central yours — you keep the copyrightSubmit your manuscript here:http://www.biomedcentral.com/info/publishing_adv.aspBioMedcentralJournal of the International Society of Sports Nutrition 2009, 6:10 http://www.jissn.com/content/6/1/10Page 2 of 2(page number not for citation purposes)CorrectionFollowing publication of our recent article [1], we noticedan error in Figure 2 A. The units of measure on the y-axisshould range from 0 to 100 pg ml-1 rather than 100–240pg ml-1 as stated in the original article.The corrected Figure 2 is presented here (Figure 1). Theresults and conclusions of this article remain unchanged.References1. Bloomer R J, Fisher-Wellman K H, Hammond K G, Schilling B K,Weber A A, Cole B J: Dietary supplement increases plasmanorepinephrine, lipolysis, and metabolic rate in resistancetrained men.  Journal of the International Society of Sports Nutrition2009, 6:4.Plasma epinephrine (A) and norepinephrine (B) data for 10 men consuming M ltdow ® and placebo i  a randomized cross- ver designFigure 1Plasma epinephrine (A) and norepinephrine (B) data for 10 men consuming Meltdown® and placebo in a randomized cross-over design. Data are mean ± SEM. * Greater norepinephrine AUC for Meltdown® compared to placebo (p = 0.03).01020304050607080901000 min 30 min 60 min 90 minEpinephrine (pg·mL-1)Meltdown®PlaceboAUC = 139±16 pg·mL-1·90min-1AUC = 129±10 pg·mL-1·90min-1A 01002003004005006000 min 30 min 60 min 90 minNorepinephrine (pg·mL-1)Meltdown®Placebo*AUC = 1332±128 pg·mL-1·90min-1AUC = 1003±133 pg·mL-1·90min-1B 

Dietary Supplement Increases Plasma Norepinephrine, Lipolysis, and Metabolic Rate in Resistance Trained Men

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Dietary supplement increases plasma norepinephrine, lipolysis, and metabolic rate in resistance trained men

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Abstract Correction to Richard J Bloomer, Kelsey H Fisher-Wellman, Kelley G Hammond, Brian K Schilling, Adrianna A Weber and Bradford J Cole: Dietary supplement increases plasma norepinephrine, lipolysis, and metabolic rate in resistance trained men. Journal of the International Society of Sports Nutrition 2009, 6: 4</p

Schilling Brian K

Hammond Kelley G

Fisher-Wellman Kelsey H

Bloomer Richard J

Weber Adrianna A

Cole Bradford J

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Abstract Background Dietary supplements targeting fat loss and increased thermogenesis are prevalent within the sport nutrition/weight loss market. While some isolated ingredients have been reported to be efficacious when used at high dosages, in particular in animal models and/or via intravenous delivery, little objective evidence is available pertaining to the efficacy of a finished product taken by human subjects in oral form. Moreover, many ingredients function as stimulants, leading to increased hemodynamic responses. The purpose of this investigation was to determine the effects of a finished dietary supplement on plasma catecholamine concentration, markers of lipolysis, metabolic rate, and hemodynamics. Methods Ten resistance trained men (age = 27 ± 4 yrs; BMI = 25 ± 3 kg· m-2; body fat = 9 ± 3%; mean ± SD) ingested a dietary supplement (Meltdown®, Vital Pharmaceuticals) or a placebo, in a random order, double blind cross-over design, with one week separating conditions. Fasting blood samples were collected before, and at 30, 60, and 90 minutes post ingestion and were assayed for epinephrine (EPI), norepinephrine (NE), glycerol, and free fatty acids (FFA). Area under the curve (AUC) was calculated for all variables. Gas samples were collected from 30–60 minutes post ingestion for measurement of metabolic rate. Heart rate and blood pressure were recorded at all blood collection times. Results AUC was greater for the dietary supplement compared to the placebo for NE (1332 ± 128 pg·mL-1·90 min-1 vs. 1003 ± 133 pg·mL-1·90 min-1; p = 0.03), glycerol (44 ± 3 μg·mL-1·90 min-1 vs. 26 ± 2 μg·mL-1·90 min-1; p -1·90 min-1 vs. 0.88 ± 0.12 mmol·L-1·90 min-1; p = 0.0003). No difference between conditions was noted for EPI AUC (p > 0.05). For all variables, values were highest at 90 minutes post ingestion. Total kilocalorie expenditure during the 30 minute collection period was 29.6% greater (p = 0.02) for the dietary supplement (35 ± 3 kcal) compared to placebo (27 ± 2 kcal). A condition main effect was noted for systolic blood pressure (p = 0.04), with values increasing from 117 ± 2 mmHg to 123 ± 2 mmHg with the dietary supplement, while remaining unchanged for placebo. No other hemodynamic changes were noted (p > 0.05). Conclusion The dietary supplement results in an acute increase in plasma NE and markers of lipolysis, as well as metabolic rate. This occurs without altering hemodynamic variables in a clinically significant manner. Intervention studies to determine the impact of this dietary supplement on weight/fat loss are warranted.</p

Background
Dietary supplements targeting fat loss and increased thermogenesis are prevalent within the sport nutrition/weight loss market. While some isolated ingredients have been reported to be efficacious when used at high dosages, in particular in animal models and/or via intravenous delivery, little objective evidence is available pertaining to the efficacy of a finished product taken by human subjects in oral form. Moreover, many ingredients function as stimulants, leading to increased hemodynamic responses. The purpose of this investigation was to determine the effects of a finished dietary supplement on plasma catecholamine concentration, markers of lipolysis, metabolic rate, and hemodynamics.  Methods
Ten resistance trained men (age = 27 ± 4 yrs; BMI = 25 ± 3 kg· m-2; body fat = 9 ± 3%; mean ± SD) ingested a dietary supplement (Meltdown®, Vital Pharmaceuticals) or a placebo, in a random order, double blind cross-over design, with one week separating conditions. Fasting blood samples were collected before, and at 30, 60, and 90 minutes post ingestion and were assayed for epinephrine (EPI), norepinephrine (NE), glycerol, and free fatty acids (FFA). Area under the curve (AUC) was calculated for all variables. Gas samples were collected from 30–60 minutes post ingestion for measurement of metabolic rate. Heart rate and blood pressure were recorded at all blood collection times.  Results
AUC was greater for the dietary supplement compared to the placebo for NE (1332 ± 128 pg·mL-1·90 min-1vs. 1003 ± 133 pg·mL-1·90 min-1; p = 0.03), glycerol (44 ± 3 μg·mL-1·90 min-1 vs. 26 ± 2 μg·mL-1·90 min-1; p \u3c 0.0001), and FFA (1.24 ± 0.17 mmol·L-1·90 min-1 vs. 0.88 ± 0.12 mmol·L-1·90 min-1; p = 0.0003). No difference between conditions was noted for EPI AUC (p \u3e 0.05). For all variables, values were highest at 90 minutes post ingestion. Total kilocalorie expenditure during the 30 minute collection period was 29.6% greater (p = 0.02) for the dietary supplement (35 ± 3 kcal) compared to placebo (27 ± 2 kcal). A condition main effect was noted for systolic blood pressure (p = 0.04), with values increasing from 117 ± 2 mmHg to 123 ± 2 mmHg with the dietary supplement, while remaining unchanged for placebo. No other hemodynamic changes were noted (p \u3e 0.05).  Conclusion
The dietary supplement results in an acute increase in plasma NE and markers of lipolysis, as well as metabolic rate. This occurs without altering hemodynamic variables in a clinically significant manner. Intervention studies to determine the impact of this dietary supplement on weight/fat loss are warranted.  Backgroun

Schilling, Brian K

Background: Dietary supplements targeting fat loss and increased thermogenesis are prevalent within the sport nutrition/weight loss market. While some isolated ingredients have been reported to be efficacious when used at high dosages, in particular in animal models and/or via intravenous delivery, little objective evidence is available pertaining to the efficacy of a finished product taken by human subjects in oral form. Moreover, many ingredients function as stimulants, leading to increased hemodynamic responses. The purpose of this investigation was to determine the effects of a finished dietary supplement on plasma catecholamine concentration, markers of lipolysis, metabolic rate, and hemodynamics. Methods: Ten resistance trained men (age = 27 ± 4 yrs; BMI = 25 ± 3 kg· m-2; body fat = 9 ± 3%; mean ± SD) ingested a dietary supplement (Meltdown®, Vital Pharmaceuticals) or a placebo, in a random order, double blind cross-over design, with one week separating conditions. Fasting blood samples were collected before, and at 30, 60, and 90 minutes post ingestion and were assayed for epinephrine (EPI), norepinephrine (NE), glycerol, and free fatty acids (FFA). Area under the curve (AUC) was calculated for all variables. Gas samples were collected from 30-60 minutes post ingestion for measurement of metabolic rate. Heart rate and blood pressure were recorded at all blood collection times. Results: AUC was greater for the dietary supplement compared to the placebo for NE (1332 ± 128 pg·mL-1·90 min-1 vs. 1003 ± 133 pg·mL-1·90 min-1; p = 0.03), glycerol (44 ± 3 μg·mL-1·90 min-1 vs. 26 ± 2 μg·mL-1·90 min-1; p \u3c 0.0001), and FFA (1.24 ± 0.17 mmol·L-1·90 min-1 vs. 0.88 ± 0.12 mmol·L-1·90 min-1; p = 0.0003). No difference between conditions was noted for EPI AUC (p 0.05). For all variables, values were highest at 90 minutes post ingestion. Total kilocalorie expenditure during the 30 minute collection period was 29.6% greater (p = 0.02) for the dietary supplement (35 ± 3 kcal) compared to placebo (27 ± 2 kcal). A condition main effect was noted for systolic blood pressure (p = 0.04), with values increasing from 117 ± 2 mmHg to 123 ± 2 mmHg with the dietary supplement, while remaining unchanged for placebo. No other hemodynamic changes were noted (p\u3c 0.05). Conclusion: The dietary supplement results in an acute increase in plasma NE and markers of lipolysis, as well as metabolic rate. This occurs without altering hemodynamic variables in a clinically significant manner. Intervention studies to determine the impact of this dietary supplement on weight/fat loss are warranted. © 2009 Bloomer et al; licensee BioMed Central Ltd

Bloomer, Richard J.

Fisher-Wellman, Kelsey H.

Hammond, Kelley G.

Schilling, Brian K.

Weber, Adrianna A.

Cole, Bradford J.

University of Memphis Digital Commons

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Dietary supplement increases plasma norepinephrine, lipolysis, and metabolic rate in resistance trained men

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