Bradford, Susan

Cottler, Linda B

Singhakant, Supachoke

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Washington University School of MedicineDigital Commons@BeckerPosters2010: Disentangling the Genetics of Alcoholism:Understanding Pathophysiology and ImprovingTreatment2010The effect of depression on alcohol use amongfemale heavy drinkers who underwent HIVprevention interventionSupachoke SinghakantWashington University School of Medicine in St. LouisSusan BradfordWashington University School of Medicine in St. LouisLinda B. CottlerWashington University School of Medicine in St. LouisFollow this and additional works at: http://digitalcommons.wustl.edu/guzeposter2010Part of the Medicine and Health Sciences CommonsThis Poster is brought to you for free and open access by the 2010: Disentangling the Genetics of Alcoholism: Understanding Pathophysiology andImproving Treatment at Digital Commons@Becker. It has been accepted for inclusion in Posters by an authorized administrator of DigitalCommons@Becker. For more information, please contact engeszer@wustl.edu.Recommended CitationSinghakant, Supachoke; Bradford, Susan; and Cottler, Linda B., "The effect of depression on alcohol use among female heavy drinkerswho underwent HIV prevention intervention" (2010). Posters. Paper 33 Samuel B. Guze Symposium on Alcoholism.http://digitalcommons.wustl.edu/guzeposter2010/33Objective: This study examined the impact of baseline depression onalcohol use among heavy drinking women.Sample: For the present analysis, 348 women who were enrolled in theSister to Sister (STS) study to explore the response of the female heavydrinkers to a peer-delivered group HIV prevention interventioncompared to a standard intervention for reducing HIV risk behaviorswere included.Findings: 32% of female heavy drinkers had Major Depression withinthe past 12 months. African American heavy drinking women were lesslikely to have depression compared to non-African American women.Heavy drinking women who had past year depression usually reportedhaving family members with depression. There were no significantdifferences in mean usual number of drinks each week and number ofabstainers among depressed and non-depressed female heavy drinkersregardless of different types of prevention interventions.Conclusion: Depression had no significant impact on alcohol useamong female heavy drinkers who underwent HIV preventionintervention. With high rate of depression, development of preventionprogram that also emphasize on detection and preventing depression inthis population are also important.Data were derived from the NIAAA-funded Sister-to-Sister (STS) study,an intervention to reduce high risk behaviors among female heavydrinkers not currently in treatment.Eligibility criteria: Female, 18 to 44 years of age, sexually active 4months prior to the interview, HIV negative, scoring at least 4 on themodified AUDIT, and urine negative for cocaine, heroin, andamphetamine use.Study protocol: Participants were randomly assigned into 2 groups.Women in group A, the Standard Intervention (SI), received only HIVcounseling. Women in group B, the Enhanced Intervention (EI), had toattend 4 peer-delivered educational group sessions.Measures: All information for the present analysis was obtained fromthe Washington University Risk Behavior Assessment (WU-RBA), PartialSubstance Abuse Model (SAM), Family History Screener (FHS), andPartial Diagnostic Interview Schedule (DIS).Past year depression: Fulfilled the criteria for the DSM-IV diagnosis ofMajor Depressive Disorder in the past 12 months at baseline.Usual number of drinks each week: Calculated from usual number ofdrinks each week in the past 12 months at baseline and at 12 months. At4 months, derived from usual number of drinks each week in the past 4months.All participants were female, mean age (N=348) was 32 years (SD=10), 75%African American, mean number of years of education was 11 years., 73%had at least one child, 58% reported having only one sex partner in the past4 months, 30% had one or more new sex partner in the past 4 months, 23%had ever traded sex for drugs or alcohol, 44% had any alcoholic familymembers, 31% had any family members with drugs problems, 35% hadfamily members with depression, mean usual number of drinks each week atbaseline was 38 drinks per week, 111 women had fulfilled the DSM-IVMajor Depression within 1 year prior to the study (32%). Thirty four peoplewho had lifetime diagnosis of Major Depression without active periodwithin 12 months before the study were excluded from further analysis(10%). Other 53 women who were not shown up either at 4 month or 12month follow up were also excluded. Depression had no significant impact on alcohol use among female heavy drinkers who underwent HIVprevention interventions. With this finding, there will be no need to exclude alcoholic people with depressionfrom studies of the treatment and prevention program for alcohol.With high rate of depression among female heavy drinkers, further development of interventions in thispopulation should also emphasize on detection and prevention of co-morbid depression.MATERIALS AND METHODSDEMOGRAPHIC DATACONCLUSIONSAcknowledgementsNIAAA (Grant number: AA12111; LB Cottler, PI)singhaks@epi.wustl.eduTHE EFFECT OF DEPRESSION ON ALCOHOL USE AMONG FEMALE HEAVY DRINKERS WHO UNDERWENTHIV PREVENTION INTERVENTIONSUPACHOKE SINGHAKANT, SUSAN BRADFORD , LINDA B. COTTLEREpidemiology and Prevention Research GroupDepartment of Psychiatry, Washington University, St. Louis, MO 63108RESULTSTable 1. Characteristics of heavy drinking women with and without past year depression at baseline Past year depression(n=93)No lifetime or past year depression (n=168)p-valueMean age 34.09 32.38 0.198EthnicityAfrican American 68% 86% 0.0006*Non-African American 32% 14%EducationMean number of years of education11.47 11.27 0.487Family HistoryHad one or more child 76% 73% 0.579Mean number of children 2.40 2.28 0.692Alcohol 51% 45% 0.659Drugs problems 34% 35% 0.832Depression 56% 26% <0.0001*Sexual Risk BehaviorHad more than one sex partner in the past 4 months29% 33% 0.389Had one or more new sex partner in the past 4 months29% 31% 0.823Had ever traded sex for drugs or alcohol32% 22% 0.103Did not always use condom during sex in the past 4 months73% 74% 0.282ABSTRACTFigure 1. Mean usual number of drinks each week by depressionBaseline 4 12depress (n=93) 42.22 19.63 21.2no depress (n=168)35.69 15.98 17.06p-value 0.3021 0.4237 0.27290102030405060Time ( months)*Statistically significant; p≤0.05Figure 2. Percentage of abstainers by depressionBaseline 4 12depress (n=93) 0 24.4 19.1no depress (n=168)0 24.7 14.0p-value 0.953 0.41705101520253035404550Time ( months)Figure 6. Percentage of abstainers by EI completion and depressionFigure 5. Mean usual number of drinks each week by EI completion and depressionFigure 4.  Percentage of abstainers by depressionFigure 3. Mean usual number of drinks each week by intent-to-treat and depressionBaseline 4 12NoD.SI (n=84) 0 22.6 23.8DEP.SI (n=53) 0 26.4 13.2NoD.EI (n=84) 0 26.2 14.3DEP.EI (n=40) 0 22.5 17.5p-value 0.923 0.31205101520253035404550Time ( months)Baseline 4 12NoD.SI (n=84) 34.26 14.95 11.1DEP.SI (n=53) 48.62 17.77 20.53NoD.EI (n=84) 37.12 17.22 23.02DEP.EI (n=40) 33.73 22.1 22.1p-value 0.344 0.774 0.040102030405060Time ( months)Baseline 4 12NoD.SI (n=125) 36.98 15.7 15.5DEP.SI (n=69) 45.71 21.88 22.9NoD.EI (n=43) 31.93 17.16 21.58DEP.EI (n=24) 32.17 13.17 18.67p-value 0.429 0.629 0.4190102030405060Time ( months)Baseline 4 12NoD.SI (n=125) 0 27.2 20.8DEP.SI (n=69) 0 27.5 11.6NoD.EI (n=43) 0 16.3 14.0DEP.EI (n=24) 0 16.7 25.0p-value 0.362 0.27305101520253035404550Time ( months)

The effect of depression on alcohol use among female heavy drinkers who underwent HIV prevention intervention

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The effect of depression on alcohol use among female heavy drinkers who underwent HIV prevention intervention

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