The emergent strain of FeLV, a novel subgroup A, was probably transmitted to panthers by a domestic cat

Abujamra

Alfred L. Roca

Benveniste

Chandhasin

Cohen

Culver

Cunningham

Denner

Donahue

Finstad

Hardy

Ishida

Jarrett

Jennifer L. Troyer

Jessup

Kumar

Maehr

Mark W. Cunningham

Meredith A. Brown

Neil

Okabe

Osofsky

Overbaugh

O’Connor

Paul-Murphy

Phipps

Pontius

Posada

Reeves

Roelke

Stephen J. O’Brien

Stewart

Thompson

Troyer

Warren E. Johnson

Yamamoto

Emerging Infectious Diseases

English

PubMed

Crossref

Genetic Characterization of Feline Leukemia Virus from Florida Panthers

From 2002 through 2005, an outbreak of feline leukemia virus (FeLV) occurred in Florida panthers (Puma concolor coryi). Clinical signs included lymphadenopathy, anemia, septicemia, and weight loss; 5 panthers died. Not associated with FeLV outcome were the genetic heritage of the panthers (pure Florida vs. Texas/Florida crosses) and co-infection with feline immunodeficiency virus. Genetic analysis of panther FeLV, designated FeLV-Pco, determined that the outbreak likely came from 1 cross-species transmission from a domestic cat. The FeLV-Pco virus was closely related to the domestic cat exogenous FeLV-A subgroup in lacking recombinant segments derived from endogenous FeLV. FeLV-Pco sequences were most similar to the well-characterized FeLV-945 strain, which is highly virulent and strongly pathogenic in domestic cats because of unique long terminal repeat and envelope sequences. These unique features may also account for the severity of the outbreak after cross-species transmission to the panther

Brown, Meredith

Cunningham, Mark W.

Roca, Alfred L.

Troyer, Jennifer L.

Johnson, Warren E.

O\u27Brien, Stephen J.

NSU Works

Directory of Open Access Journals

A virus-like particle associated with leukemia (lymphosarcoma).

Avoiding the lurking pitfalls in Florida panther recovery. Wild Soc Bull.

Epidemiologic and clinical aspects of feline immunodeﬁ -ciency virus infection in cats from the continental United States and Canada and possible mode of transmission.

Epizootiologic association between feline immunodeﬁ ciency virus infection and feline leukemia virus seropositivity. J Am Vet Med Assoc.

Epizootiology and management of feline leukemia virus in the Florida puma. J Wildl Dis.

Feline immunodeﬁ ciency virus infection in cats of Japan.

Feline lentivirus and feline oncovirus status of free-ranging lions (Panthera leo), leopards (Panthera pardus), and cheetahs (Acinonyx jubatus) in Botswana: a regional perspective. J Zoo Wildl Med.

Feline leukaemia virus LTR variation and disease association in a geographical and temporal cluster.

Feline leukaemia virus: generation of pathogenic and oncogenic variants. Curr Top Microbiol Immunol.

Feline leukemia virus infection and renal spirochetosis in a free-ranging cougar (Felis concolor).

FeLV-related sequences in DNA from a FeLV-free cat colony.

Genomic ancestry of the American puma (Puma concolor).

Horizontal transmission of feline leukaemia virus.

How does HIV induce AIDS? The virus protein hypothesis.

Inhibition of feline leukemia virus subgroup A infection by coinoculation with subgroup B.

Initial sequence and comparative analysis of the cat genome. Genome Res.

MacClade 3.05. Sunderland (MA): Sinauer Associates;

MEGA3: Integrated software for molecular evolutionary genetics analysis and sequence alignment. Brief Bioinform.

MODELTEST: testing the model of DNA substitution.

Molecular aspects of feline leukemia virus pathogenesis.

Molecular genetic characterization of the RD-114 gene family of endogenous feline retroviral sequences.

Mutations that abrogate transactivational activity of the feline leukemia virus long terminal repeat do not affect virus replication.

Nucleotide sequences of a feline leukemia virus subgroup A envelope gene and long terminal repeat and evidence for the recombinational origin of subgroup B viruses.

Prevalence of feline leukemia virus infection and serum antibodies against feline immunodeﬁ ciency virus in unowned free-roaming cats.

Regulation of FeLV945 by c-Myb binding and CBP recruitment to the LTR.

Segregation of RD-114 and FeLV-related sequences in crosses between domestic cat and leopard cat.

Selection forces and constraints on retroviral sequence variation.

Serologic survey and serum biochemical reference ranges of the freeranging mountain lion (Felis concolor) in California. J Wildl Dis.

Seroprevalence and genomic divergence of circulating strains of feline immunodeﬁ ciency virus among Felidae and Hyaenidae species.

Seroprevalence of infectious disease agents in free-ranging Florida panthers (Felis concolor coryi).

Subtle mutational changes in the SU protein of a natural feline leukemia virus subgroup A isolate alter disease spectrum.

T-lymphocyte proﬁ les in FIV-infected wild lions and pumas reveal CD4 depletion. J Wildl Dis.

The CLUSTAL X windows interface: ﬂ exible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res.

The consequences of demographic reduction and genetic depletion in the endangered Florida panther. Curr Biol.

Unique long terminal repeat and surface glycoprotein gene sequences of feline leukemia virus as determinants of disease outcome.

Viral genetic determinants of T-cell killing and immunodeﬁ ciency disease induction by the feline leukemia virus

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2600209

Genetic Characterization of Feline Leukemia Virus from Florida Panthers

Abstract

Similar works

Full text

Available Versions

Crossref

NSU Works

Directory of Open Access Journals